Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs

It is well established that gastrointestinal (GI) cancers are common and devastating diseases around the world. Despite the significant progress that has been made in the treatment of GI cancers, the mortality rates remain high, indicating a real need to explore the complex pathogenesis and develop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhen Zeng, Chunxiang Ma, Kexin Chen, Mingshan Jiang, Reshma Vasu, Rui Liu, Yinglan Zhao, Hu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	G protein-coupled receptors colorectal cancer gastric cancer esophageal cancer drug discovery Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6590a34b16c14e52ab7b1daabc6f9e49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6590a34b16c14e52ab7b1daabc6f9e49
record_format	dspace
spelling	oai:doaj.org-article:6590a34b16c14e52ab7b1daabc6f9e492021-11-25T17:10:07ZRoles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs10.3390/cells101129882073-4409https://doaj.org/article/6590a34b16c14e52ab7b1daabc6f9e492021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2988https://doaj.org/toc/2073-4409It is well established that gastrointestinal (GI) cancers are common and devastating diseases around the world. Despite the significant progress that has been made in the treatment of GI cancers, the mortality rates remain high, indicating a real need to explore the complex pathogenesis and develop more effective therapeutics for GI cancers. G protein-coupled receptors (GPCRs) are critical signaling molecules involved in various biological processes including cell growth, proliferation, and death, as well as immune responses and inflammation regulation. Substantial evidence has demonstrated crucial roles of GPCRs in the development of GI cancers, which provided an impetus for further research regarding the pathophysiological mechanisms and drug discovery of GI cancers. In this review, we mainly discuss the roles of sphingosine 1-phosphate receptors (S1PRs), angiotensin II receptors, estrogen-related GPCRs, and some other important GPCRs in the development of colorectal, gastric, and esophageal cancer, and explore the potential of GPCRs as therapeutic targets.Zhen ZengChunxiang MaKexin ChenMingshan JiangReshma VasuRui LiuYinglan ZhaoHu ZhangMDPI AGarticleG protein-coupled receptorscolorectal cancergastric canceresophageal cancerdrug discoveryBiology (General)QH301-705.5ENCells, Vol 10, Iss 2988, p 2988 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	G protein-coupled receptors colorectal cancer gastric cancer esophageal cancer drug discovery Biology (General) QH301-705.5
spellingShingle	G protein-coupled receptors colorectal cancer gastric cancer esophageal cancer drug discovery Biology (General) QH301-705.5 Zhen Zeng Chunxiang Ma Kexin Chen Mingshan Jiang Reshma Vasu Rui Liu Yinglan Zhao Hu Zhang Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
description	It is well established that gastrointestinal (GI) cancers are common and devastating diseases around the world. Despite the significant progress that has been made in the treatment of GI cancers, the mortality rates remain high, indicating a real need to explore the complex pathogenesis and develop more effective therapeutics for GI cancers. G protein-coupled receptors (GPCRs) are critical signaling molecules involved in various biological processes including cell growth, proliferation, and death, as well as immune responses and inflammation regulation. Substantial evidence has demonstrated crucial roles of GPCRs in the development of GI cancers, which provided an impetus for further research regarding the pathophysiological mechanisms and drug discovery of GI cancers. In this review, we mainly discuss the roles of sphingosine 1-phosphate receptors (S1PRs), angiotensin II receptors, estrogen-related GPCRs, and some other important GPCRs in the development of colorectal, gastric, and esophageal cancer, and explore the potential of GPCRs as therapeutic targets.
format	article
author	Zhen Zeng Chunxiang Ma Kexin Chen Mingshan Jiang Reshma Vasu Rui Liu Yinglan Zhao Hu Zhang
author_facet	Zhen Zeng Chunxiang Ma Kexin Chen Mingshan Jiang Reshma Vasu Rui Liu Yinglan Zhao Hu Zhang
author_sort	Zhen Zeng
title	Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
title_short	Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
title_full	Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
title_fullStr	Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
title_full_unstemmed	Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
title_sort	roles of g protein-coupled receptors (gpcrs) in gastrointestinal cancers: focus on sphingosine 1-shosphate receptors, angiotensin ii receptors, and estrogen-related gpcrs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6590a34b16c14e52ab7b1daabc6f9e49
work_keys_str_mv	AT zhenzeng rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT chunxiangma rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT kexinchen rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT mingshanjiang rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT reshmavasu rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT ruiliu rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT yinglanzhao rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs AT huzhang rolesofgproteincoupledreceptorsgpcrsingastrointestinalcancersfocusonsphingosine1shosphatereceptorsangiotensiniireceptorsandestrogenrelatedgpcrs
_version_	1718412653794164736

Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs

Ejemplares similares