KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
The methanolic extract obtained from Cecropia membranacea Trécul (0,5 g/kg v.o.) administered to mice albinos ICR, elicits antiseizure activity (73% of protection) in mice exposed to pentilentetrazol (PTZ, 80 mg/kg, sc.), chemical model of absence crisis. Additionally, the extract conferred signific...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
Universidad de Antioquia
2009
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| Subjects: | |
| Online Access: | https://doaj.org/article/65912be8488547dda5c27b216cdc2276 |
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| Summary: | The methanolic extract obtained from Cecropia membranacea Trécul (0,5 g/kg v.o.) administered to mice
albinos ICR, elicits antiseizure activity (73% of protection) in mice exposed to pentilentetrazol (PTZ, 80
mg/kg, sc.), chemical model of absence crisis. Additionally, the extract conferred significant protection
against the maximal electroshock seizure, model of tonic clonic seizures and the parameter of frequency in
the elevated plus maze test, screening model of anxiety. On the other hand, the extract lacked effect on the
pentobarbitone induced sleep test and in the forced swimming test, screening model for antidepressants.
Phytochemical preliminary analysis showed presence of tannin, terpenoid and flavonoid metabolites.
This study suggests that C. membranacea could be source of substances with anticonvulsant and anxiolitic
properties.
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