KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>

The methanolic extract obtained from Cecropia membranacea Trécul (0,5 g/kg v.o.) administered to mice albinos ICR, elicits antiseizure activity (73% of protection) in mice exposed to pentilentetrazol (PTZ, 80 mg/kg, sc.), chemical model of absence crisis. Additionally, the extract conferred signific...

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Autores principales:	Dúmar A. JARAMILLO H., Javier RINCÓN V., Mario F. GUERRERO P.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Cecropia pentylenetetrazole electroshock terpenoids flavonoids Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/65912be8488547dda5c27b216cdc2276
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spelling	oai:doaj.org-article:65912be8488547dda5c27b216cdc22762021-11-19T04:17:13ZKIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>0121-40042145-2660https://doaj.org/article/65912be8488547dda5c27b216cdc22762009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/799https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The methanolic extract obtained from Cecropia membranacea Trécul (0,5 g/kg v.o.) administered to mice albinos ICR, elicits antiseizure activity (73% of protection) in mice exposed to pentilentetrazol (PTZ, 80 mg/kg, sc.), chemical model of absence crisis. Additionally, the extract conferred significant protection against the maximal electroshock seizure, model of tonic clonic seizures and the parameter of frequency in the elevated plus maze test, screening model of anxiety. On the other hand, the extract lacked effect on the pentobarbitone induced sleep test and in the forced swimming test, screening model for antidepressants. Phytochemical preliminary analysis showed presence of tannin, terpenoid and flavonoid metabolites. This study suggests that C. membranacea could be source of substances with anticonvulsant and anxiolitic properties. Dúmar A. JARAMILLO H.Javier RINCÓN V.Mario F. GUERRERO P.Universidad de AntioquiaarticleCecropiapentylenetetrazoleelectroshockterpenoidsflavonoidsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cecropia pentylenetetrazole electroshock terpenoids flavonoids Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Cecropia pentylenetetrazole electroshock terpenoids flavonoids Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Dúmar A. JARAMILLO H. Javier RINCÓN V. Mario F. GUERRERO P. KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
description	The methanolic extract obtained from Cecropia membranacea Trécul (0,5 g/kg v.o.) administered to mice albinos ICR, elicits antiseizure activity (73% of protection) in mice exposed to pentilentetrazol (PTZ, 80 mg/kg, sc.), chemical model of absence crisis. Additionally, the extract conferred significant protection against the maximal electroshock seizure, model of tonic clonic seizures and the parameter of frequency in the elevated plus maze test, screening model of anxiety. On the other hand, the extract lacked effect on the pentobarbitone induced sleep test and in the forced swimming test, screening model for antidepressants. Phytochemical preliminary analysis showed presence of tannin, terpenoid and flavonoid metabolites. This study suggests that C. membranacea could be source of substances with anticonvulsant and anxiolitic properties.
format	article
author	Dúmar A. JARAMILLO H. Javier RINCÓN V. Mario F. GUERRERO P.
author_facet	Dúmar A. JARAMILLO H. Javier RINCÓN V. Mario F. GUERRERO P.
author_sort	Dúmar A. JARAMILLO H.
title	KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
title_short	KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
title_full	KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
title_fullStr	KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
title_full_unstemmed	KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>
title_sort	kind of activity antiabsence in mice produced by the methanolic extract from <i>cecropia membranacea trécul</i>
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/65912be8488547dda5c27b216cdc2276
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KIND OF ACTIVITY ANTIABSENCE IN MICE PRODUCED BY THE METHANOLIC EXTRACT FROM <I>Cecropia Membranacea Trécul</I>

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