Mutational signatures of ionizing radiation in second malignancies

Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balance...

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Autores principales:	Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
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spelling	oai:doaj.org-article:6591661632a94c5d9e36a5a48f8dcf2c2021-12-02T14:39:48ZMutational signatures of ionizing radiation in second malignancies10.1038/ncomms126052041-1723https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12605https://doaj.org/toc/2041-1723Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.Sam BehjatiGunes GundemDavid C. WedgeNicola D. RobertsPatrick S. TarpeySusanna L. CookePeter Van LooLudmil B. AlexandrovManasa RamakrishnaHelen DaviesSerena Nik-ZainalClaire HardyCalli LatimerKeiran M. RaineLucy StebbingsAndy MenziesDavid JonesRebecca ShepherdAdam P. ButlerJon W. TeagueMette JorgensenBhavisha KhatriNischalan PillayAdam ShlienP. Andrew FutrealChristophe BadieICGC Prostate GroupUltan McDermottG. Steven BovaAndrea L. RichardsonAdrienne M. FlanaganMichael R. StrattonPeter J. CampbellNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell Mutational signatures of ionizing radiation in second malignancies
description	Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.
format	article
author	Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell
author_facet	Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell
author_sort	Sam Behjati
title	Mutational signatures of ionizing radiation in second malignancies
title_short	Mutational signatures of ionizing radiation in second malignancies
title_full	Mutational signatures of ionizing radiation in second malignancies
title_fullStr	Mutational signatures of ionizing radiation in second malignancies
title_full_unstemmed	Mutational signatures of ionizing radiation in second malignancies
title_sort	mutational signatures of ionizing radiation in second malignancies
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
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Mutational signatures of ionizing radiation in second malignancies

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