The effect of systemic administration of salicylate on the auditory cortex of guinea pigs

<h4>Objective</h4> To investigate the effect of systemic administration of salicylate as a tinnitus inducing drug in the auditory cortex of guinea pigs. <h4>Methods</h4> Extracellular recording of spikes of the primary auditory cortex and dorsocaudal areas in healthy male alb...

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Autores principales:	Mutsumi Kenmochi, Kentaro Ochi, Hirotsugu Kinoshita, Yasuhiro Miyamoto, Izumi Koizuka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/659981cce15641f48e316159c149c43b
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spelling	oai:doaj.org-article:659981cce15641f48e316159c149c43b2021-11-18T08:14:36ZThe effect of systemic administration of salicylate on the auditory cortex of guinea pigs1932-6203https://doaj.org/article/659981cce15641f48e316159c149c43b2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584678/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> To investigate the effect of systemic administration of salicylate as a tinnitus inducing drug in the auditory cortex of guinea pigs. <h4>Methods</h4> Extracellular recording of spikes of the primary auditory cortex and dorsocaudal areas in healthy male albino Hartley guinea pigs was continuously performed (pre- and post-salicylate). <h4>Results</h4> We recorded 160 single units in the primary auditory cortex from five guinea pigs and 156 single units in the dorsocaudal area from another five guinea pigs. The threshold was significantly elevated after the administration of salicylate in both the primary auditory cortex and dorsocaudal areas. The Q10dB value was significantly increased in the primary auditory cortex, whereas it has significantly decreased in the dorsocaudal area. Spontaneous firing activity was significantly decreased in the primary auditory cortex, whereas it has significantly increased in the dorsocaudal area. <h4>Conclusion</h4> Salicylate induces significant changes in single units of both stimulated and spontaneous activity in the auditory cortex of guinea pigs. The spontaneous activity changed differently depending on its cortical areas, which may be due to the neural elements that generate tinnitus.Mutsumi KenmochiKentaro OchiHirotsugu KinoshitaYasuhiro MiyamotoIzumi KoizukaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mutsumi Kenmochi Kentaro Ochi Hirotsugu Kinoshita Yasuhiro Miyamoto Izumi Koizuka The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
description	<h4>Objective</h4> To investigate the effect of systemic administration of salicylate as a tinnitus inducing drug in the auditory cortex of guinea pigs. <h4>Methods</h4> Extracellular recording of spikes of the primary auditory cortex and dorsocaudal areas in healthy male albino Hartley guinea pigs was continuously performed (pre- and post-salicylate). <h4>Results</h4> We recorded 160 single units in the primary auditory cortex from five guinea pigs and 156 single units in the dorsocaudal area from another five guinea pigs. The threshold was significantly elevated after the administration of salicylate in both the primary auditory cortex and dorsocaudal areas. The Q10dB value was significantly increased in the primary auditory cortex, whereas it has significantly decreased in the dorsocaudal area. Spontaneous firing activity was significantly decreased in the primary auditory cortex, whereas it has significantly increased in the dorsocaudal area. <h4>Conclusion</h4> Salicylate induces significant changes in single units of both stimulated and spontaneous activity in the auditory cortex of guinea pigs. The spontaneous activity changed differently depending on its cortical areas, which may be due to the neural elements that generate tinnitus.
format	article
author	Mutsumi Kenmochi Kentaro Ochi Hirotsugu Kinoshita Yasuhiro Miyamoto Izumi Koizuka
author_facet	Mutsumi Kenmochi Kentaro Ochi Hirotsugu Kinoshita Yasuhiro Miyamoto Izumi Koizuka
author_sort	Mutsumi Kenmochi
title	The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
title_short	The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
title_full	The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
title_fullStr	The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
title_full_unstemmed	The effect of systemic administration of salicylate on the auditory cortex of guinea pigs
title_sort	effect of systemic administration of salicylate on the auditory cortex of guinea pigs
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/659981cce15641f48e316159c149c43b
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The effect of systemic administration of salicylate on the auditory cortex of guinea pigs

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