Notch-independent RBPJ controls angiogenesis in the adult heart

Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ramón Díaz-Trelles, Maria Cecilia Scimia, Paul Bushway, Danh Tran, Anna Monosov, Edward Monosov, Kirk Peterson, Stacey Rentschler, Pedro Cabrales, Pilar Ruiz-Lozano, Mark Mercola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/659bd0f4ce584ff8ab4fcf19cbaacd4d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:659bd0f4ce584ff8ab4fcf19cbaacd4d
record_format	dspace
spelling	oai:doaj.org-article:659bd0f4ce584ff8ab4fcf19cbaacd4d2021-12-02T16:57:39ZNotch-independent RBPJ controls angiogenesis in the adult heart10.1038/ncomms120882041-1723https://doaj.org/article/659bd0f4ce584ff8ab4fcf19cbaacd4d2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12088https://doaj.org/toc/2041-1723Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to treat heart injury.Ramón Díaz-TrellesMaria Cecilia ScimiaPaul BushwayDanh TranAnna MonosovEdward MonosovKirk PetersonStacey RentschlerPedro CabralesPilar Ruiz-LozanoMark MercolaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramón Díaz-Trelles Maria Cecilia Scimia Paul Bushway Danh Tran Anna Monosov Edward Monosov Kirk Peterson Stacey Rentschler Pedro Cabrales Pilar Ruiz-Lozano Mark Mercola Notch-independent RBPJ controls angiogenesis in the adult heart
description	Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to treat heart injury.
format	article
author	Ramón Díaz-Trelles Maria Cecilia Scimia Paul Bushway Danh Tran Anna Monosov Edward Monosov Kirk Peterson Stacey Rentschler Pedro Cabrales Pilar Ruiz-Lozano Mark Mercola
author_facet	Ramón Díaz-Trelles Maria Cecilia Scimia Paul Bushway Danh Tran Anna Monosov Edward Monosov Kirk Peterson Stacey Rentschler Pedro Cabrales Pilar Ruiz-Lozano Mark Mercola
author_sort	Ramón Díaz-Trelles
title	Notch-independent RBPJ controls angiogenesis in the adult heart
title_short	Notch-independent RBPJ controls angiogenesis in the adult heart
title_full	Notch-independent RBPJ controls angiogenesis in the adult heart
title_fullStr	Notch-independent RBPJ controls angiogenesis in the adult heart
title_full_unstemmed	Notch-independent RBPJ controls angiogenesis in the adult heart
title_sort	notch-independent rbpj controls angiogenesis in the adult heart
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/659bd0f4ce584ff8ab4fcf19cbaacd4d
work_keys_str_mv	AT ramondiaztrelles notchindependentrbpjcontrolsangiogenesisintheadultheart AT mariaceciliascimia notchindependentrbpjcontrolsangiogenesisintheadultheart AT paulbushway notchindependentrbpjcontrolsangiogenesisintheadultheart AT danhtran notchindependentrbpjcontrolsangiogenesisintheadultheart AT annamonosov notchindependentrbpjcontrolsangiogenesisintheadultheart AT edwardmonosov notchindependentrbpjcontrolsangiogenesisintheadultheart AT kirkpeterson notchindependentrbpjcontrolsangiogenesisintheadultheart AT staceyrentschler notchindependentrbpjcontrolsangiogenesisintheadultheart AT pedrocabrales notchindependentrbpjcontrolsangiogenesisintheadultheart AT pilarruizlozano notchindependentrbpjcontrolsangiogenesisintheadultheart AT markmercola notchindependentrbpjcontrolsangiogenesisintheadultheart
_version_	1718382504416641024

Notch-independent RBPJ controls angiogenesis in the adult heart

Ejemplares similares