ROS-Based Nanoparticles for Atherosclerosis Treatment

Atherosclerosis (AS), a chronic arterial disease, is the leading cause of death in western developed countries. Considering its long-term asymptomatic progression and serious complications, the early prevention and effective treatment of AS are particularly important. The unique characteristics of n...

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Autores principales:	Xin Hu, Pengxuan Zhao, Yongping Lu, Yani Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	reactive oxygen species (ROS) atherosclerosis nanoparticles scavenger ROS-responsive therapy Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/659d79775ef74109a638eb3ea9aec8f7
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id	oai:doaj.org-article:659d79775ef74109a638eb3ea9aec8f7
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spelling	oai:doaj.org-article:659d79775ef74109a638eb3ea9aec8f72021-11-25T18:14:47ZROS-Based Nanoparticles for Atherosclerosis Treatment10.3390/ma142269211996-1944https://doaj.org/article/659d79775ef74109a638eb3ea9aec8f72021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6921https://doaj.org/toc/1996-1944Atherosclerosis (AS), a chronic arterial disease, is the leading cause of death in western developed countries. Considering its long-term asymptomatic progression and serious complications, the early prevention and effective treatment of AS are particularly important. The unique characteristics of nanoparticles (NPs) make them attractive in novel therapeutic and diagnostic applications, providing new options for the treatment of AS. With the assistance of reactive oxygen species (ROS)-based NPs, drugs can reach specific lesion areas, prolong the therapeutic effect, achieve targeted controlled release and reduce adverse side effects. In this article, we reviewed the mechanism of AS and the generation and removal strategy of ROS. We further discussed ROS-based NPs, and summarized their biomedical applications in scavenger and drug delivery. Furthermore, we highlighted the recent advances, challenges and future perspectives of ROS-based NPs for treating AS.Xin HuPengxuan ZhaoYongping LuYani LiuMDPI AGarticlereactive oxygen species (ROS)atherosclerosisnanoparticlesscavengerROS-responsive therapyTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6921, p 6921 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive oxygen species (ROS) atherosclerosis nanoparticles scavenger ROS-responsive therapy Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	reactive oxygen species (ROS) atherosclerosis nanoparticles scavenger ROS-responsive therapy Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Xin Hu Pengxuan Zhao Yongping Lu Yani Liu ROS-Based Nanoparticles for Atherosclerosis Treatment
description	Atherosclerosis (AS), a chronic arterial disease, is the leading cause of death in western developed countries. Considering its long-term asymptomatic progression and serious complications, the early prevention and effective treatment of AS are particularly important. The unique characteristics of nanoparticles (NPs) make them attractive in novel therapeutic and diagnostic applications, providing new options for the treatment of AS. With the assistance of reactive oxygen species (ROS)-based NPs, drugs can reach specific lesion areas, prolong the therapeutic effect, achieve targeted controlled release and reduce adverse side effects. In this article, we reviewed the mechanism of AS and the generation and removal strategy of ROS. We further discussed ROS-based NPs, and summarized their biomedical applications in scavenger and drug delivery. Furthermore, we highlighted the recent advances, challenges and future perspectives of ROS-based NPs for treating AS.
format	article
author	Xin Hu Pengxuan Zhao Yongping Lu Yani Liu
author_facet	Xin Hu Pengxuan Zhao Yongping Lu Yani Liu
author_sort	Xin Hu
title	ROS-Based Nanoparticles for Atherosclerosis Treatment
title_short	ROS-Based Nanoparticles for Atherosclerosis Treatment
title_full	ROS-Based Nanoparticles for Atherosclerosis Treatment
title_fullStr	ROS-Based Nanoparticles for Atherosclerosis Treatment
title_full_unstemmed	ROS-Based Nanoparticles for Atherosclerosis Treatment
title_sort	ros-based nanoparticles for atherosclerosis treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/659d79775ef74109a638eb3ea9aec8f7
work_keys_str_mv	AT xinhu rosbasednanoparticlesforatherosclerosistreatment AT pengxuanzhao rosbasednanoparticlesforatherosclerosistreatment AT yongpinglu rosbasednanoparticlesforatherosclerosistreatment AT yaniliu rosbasednanoparticlesforatherosclerosistreatment
_version_	1718411440928325632

ROS-Based Nanoparticles for Atherosclerosis Treatment

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