Identification of common predictors of surgical outcomes for epilepsy surgery

Jing Zhang,1 Weifang Liu,1 Hui Chen,1 Hong Xia,1 Zhen Zhou,1 Shanshan Mei,2 Qingzhu Liu,2 Yunlin Li21School of Biomedical Engineering, Capital Medical University, 2Department of Functional Neurology and Neurosurgery, Beijing Haidian Hospital, Beijing, People's Republic of ChinaAbstract: Alth...

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Autores principales:	Zhang J, Liu W, Chen H, Xia H, Zhou Z, Mei S, Liu Q, Li Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/65a0194d62194a5f906f40c50bf50d55
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spelling	oai:doaj.org-article:65a0194d62194a5f906f40c50bf50d552021-12-02T08:34:23ZIdentification of common predictors of surgical outcomes for epilepsy surgery1176-63281178-2021https://doaj.org/article/65a0194d62194a5f906f40c50bf50d552013-11-01T00:00:00Zhttp://www.dovepress.com/identification-of-common-predictors-of-surgical-outcomes-for-epilepsy--a14904https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jing Zhang,1 Weifang Liu,1 Hui Chen,1 Hong Xia,1 Zhen Zhou,1 Shanshan Mei,2 Qingzhu Liu,2 Yunlin Li21School of Biomedical Engineering, Capital Medical University, 2Department of Functional Neurology and Neurosurgery, Beijing Haidian Hospital, Beijing, People's Republic of ChinaAbstract: Although epilepsy surgery is an effective treatment for patients with drug-resistant epilepsy, surgical outcomes vary across patient groups and studies. Identification of reliable prognostic factors for surgical outcome is important for outcome research. In this study, recent systematic reviews and meta-analyses on prediction of seizure outcome have been analyzed, and common predictors of seizure outcome or unrelated factors for temporal lobe epilepsy (TLE), lesional extratemporal lobe epilepsy (ETLE), and tuberous sclerosis complex have been identified. Clinical factors such as lesional epilepsy, abnormal magnetic resonance imaging, partial seizures, and complete resection were found to be common positive predictors, and factors such as nonlesional epilepsy, poorly defined and localized epileptic focus, generalized seizures, and incomplete resection are common negative predictors, while factors such as age at surgery and side of surgery are unrelated to seizure outcome for TLE and lesional ETLE. In addition, diagnostic neuroimaging and resection are among the most important predictors of seizure outcome. However, common predictors of seizure outcome could not be identified in nonlesional ETLE because no predictors were found to be significant in adult patients (by meta-analysis), and outcome prediction is difficult in this case. Meta-analysis of other outcomes, such as neuropsychologic outcomes, is rare due to lack of evaluation standards. Further studies on identification of reliable predictors of surgical outcomes are needed.Keywords: neuroimaging, epilepsy surgery, outcome prediction, common predictorsZhang JLiu WChen HXia HZhou ZMei SLiu QLi YDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1673-1682 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang J Liu W Chen H Xia H Zhou Z Mei S Liu Q Li Y Identification of common predictors of surgical outcomes for epilepsy surgery
description	Jing Zhang,1 Weifang Liu,1 Hui Chen,1 Hong Xia,1 Zhen Zhou,1 Shanshan Mei,2 Qingzhu Liu,2 Yunlin Li21School of Biomedical Engineering, Capital Medical University, 2Department of Functional Neurology and Neurosurgery, Beijing Haidian Hospital, Beijing, People's Republic of ChinaAbstract: Although epilepsy surgery is an effective treatment for patients with drug-resistant epilepsy, surgical outcomes vary across patient groups and studies. Identification of reliable prognostic factors for surgical outcome is important for outcome research. In this study, recent systematic reviews and meta-analyses on prediction of seizure outcome have been analyzed, and common predictors of seizure outcome or unrelated factors for temporal lobe epilepsy (TLE), lesional extratemporal lobe epilepsy (ETLE), and tuberous sclerosis complex have been identified. Clinical factors such as lesional epilepsy, abnormal magnetic resonance imaging, partial seizures, and complete resection were found to be common positive predictors, and factors such as nonlesional epilepsy, poorly defined and localized epileptic focus, generalized seizures, and incomplete resection are common negative predictors, while factors such as age at surgery and side of surgery are unrelated to seizure outcome for TLE and lesional ETLE. In addition, diagnostic neuroimaging and resection are among the most important predictors of seizure outcome. However, common predictors of seizure outcome could not be identified in nonlesional ETLE because no predictors were found to be significant in adult patients (by meta-analysis), and outcome prediction is difficult in this case. Meta-analysis of other outcomes, such as neuropsychologic outcomes, is rare due to lack of evaluation standards. Further studies on identification of reliable predictors of surgical outcomes are needed.Keywords: neuroimaging, epilepsy surgery, outcome prediction, common predictors
format	article
author	Zhang J Liu W Chen H Xia H Zhou Z Mei S Liu Q Li Y
author_facet	Zhang J Liu W Chen H Xia H Zhou Z Mei S Liu Q Li Y
author_sort	Zhang J
title	Identification of common predictors of surgical outcomes for epilepsy surgery
title_short	Identification of common predictors of surgical outcomes for epilepsy surgery
title_full	Identification of common predictors of surgical outcomes for epilepsy surgery
title_fullStr	Identification of common predictors of surgical outcomes for epilepsy surgery
title_full_unstemmed	Identification of common predictors of surgical outcomes for epilepsy surgery
title_sort	identification of common predictors of surgical outcomes for epilepsy surgery
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/65a0194d62194a5f906f40c50bf50d55
work_keys_str_mv	AT zhangj identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT liuw identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT chenh identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT xiah identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT zhouz identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT meis identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT liuq identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery AT liy identificationofcommonpredictorsofsurgicaloutcomesforepilepsysurgery
_version_	1718398489814106112

Identification of common predictors of surgical outcomes for epilepsy surgery

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