Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disru...

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Autores principales:	Jiaqiang Dong, Jiong Li, Yang Li, Zhikun Ma, Yongxin Yu, Cun-Yu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65a0996e08e9453696eacebfb2075399
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spelling	oai:doaj.org-article:65a0996e08e9453696eacebfb20753992021-12-02T17:45:00ZTranscriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma10.1038/s41467-021-24137-12041-1723https://doaj.org/article/65a0996e08e9453696eacebfb20753992021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24137-1https://doaj.org/toc/2041-1723Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.Jiaqiang DongJiong LiYang LiZhikun MaYongxin YuCun-Yu WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiaqiang Dong Jiong Li Yang Li Zhikun Ma Yongxin Yu Cun-Yu Wang Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
description	Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.
format	article
author	Jiaqiang Dong Jiong Li Yang Li Zhikun Ma Yongxin Yu Cun-Yu Wang
author_facet	Jiaqiang Dong Jiong Li Yang Li Zhikun Ma Yongxin Yu Cun-Yu Wang
author_sort	Jiaqiang Dong
title	Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_short	Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_full	Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_fullStr	Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_full_unstemmed	Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_sort	transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65a0996e08e9453696eacebfb2075399
work_keys_str_mv	AT jiaqiangdong transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma AT jiongli transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma AT yangli transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma AT zhikunma transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma AT yongxinyu transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma AT cunyuwang transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
_version_	1718379591040499712

Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

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