Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix

Martin Strnad, Yoo Jin Oh, and colleagues use single-molecule force spectroscopy and an extracellular matrix (ECM) analog that mimics natural tick feeding to show that the surface proteins DbpA/B can enhance spirochete motility in the ECM of the host. These results show that spirochetes can tune the...

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Autores principales:	Martin Strnad, Yoo Jin Oh, Marie Vancová, Lisa Hain, Jemiina Salo, Libor Grubhoffer, Jana Nebesářová, Jukka Hytönen, Peter Hinterdorfer, Ryan O. M. Rego
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/65a4204d09884ed9a36dd4375769f990
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spelling	oai:doaj.org-article:65a4204d09884ed9a36dd4375769f9902021-12-02T13:33:50ZNanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix10.1038/s42003-021-01783-12399-3642https://doaj.org/article/65a4204d09884ed9a36dd4375769f9902021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01783-1https://doaj.org/toc/2399-3642Martin Strnad, Yoo Jin Oh, and colleagues use single-molecule force spectroscopy and an extracellular matrix (ECM) analog that mimics natural tick feeding to show that the surface proteins DbpA/B can enhance spirochete motility in the ECM of the host. These results show that spirochetes can tune their transient molecular binding to ECM components to enhance spirochetal dissemination through the host.Martin StrnadYoo Jin OhMarie VancováLisa HainJemiina SaloLibor GrubhofferJana NebesářováJukka HytönenPeter HinterdorferRyan O. M. RegoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Martin Strnad Yoo Jin Oh Marie Vancová Lisa Hain Jemiina Salo Libor Grubhoffer Jana Nebesářová Jukka Hytönen Peter Hinterdorfer Ryan O. M. Rego Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
description	Martin Strnad, Yoo Jin Oh, and colleagues use single-molecule force spectroscopy and an extracellular matrix (ECM) analog that mimics natural tick feeding to show that the surface proteins DbpA/B can enhance spirochete motility in the ECM of the host. These results show that spirochetes can tune their transient molecular binding to ECM components to enhance spirochetal dissemination through the host.
format	article
author	Martin Strnad Yoo Jin Oh Marie Vancová Lisa Hain Jemiina Salo Libor Grubhoffer Jana Nebesářová Jukka Hytönen Peter Hinterdorfer Ryan O. M. Rego
author_facet	Martin Strnad Yoo Jin Oh Marie Vancová Lisa Hain Jemiina Salo Libor Grubhoffer Jana Nebesářová Jukka Hytönen Peter Hinterdorfer Ryan O. M. Rego
author_sort	Martin Strnad
title	Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
title_short	Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
title_full	Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
title_fullStr	Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
title_full_unstemmed	Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix
title_sort	nanomechanical mechanisms of lyme disease spirochete motility enhancement in extracellular matrix
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65a4204d09884ed9a36dd4375769f990
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Nanomechanical mechanisms of Lyme disease spirochete motility enhancement in extracellular matrix

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