Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.

Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was m...

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Autores principales:	Seong Beom Ahn, Abidali Mohamedali, Charles Chan, Julie Fletcher, Sun Young Kwun, Candice Clarke, Owen F Dent, Pierre H Chapuis, Edouard Nice, Mark S Baker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65a42582e5fe46279181117d3f911493
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spelling	oai:doaj.org-article:65a42582e5fe46279181117d3f9114932021-11-18T08:19:39ZCorrelations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.1932-620310.1371/journal.pone.0097248https://doaj.org/article/65a42582e5fe46279181117d3f9114932014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24821188/?tool=EBIhttps://doaj.org/toc/1932-6203Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.Seong Beom AhnAbidali MohamedaliCharles ChanJulie FletcherSun Young KwunCandice ClarkeOwen F DentPierre H ChapuisEdouard NiceMark S BakerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97248 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seong Beom Ahn Abidali Mohamedali Charles Chan Julie Fletcher Sun Young Kwun Candice Clarke Owen F Dent Pierre H Chapuis Edouard Nice Mark S Baker Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
description	Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
format	article
author	Seong Beom Ahn Abidali Mohamedali Charles Chan Julie Fletcher Sun Young Kwun Candice Clarke Owen F Dent Pierre H Chapuis Edouard Nice Mark S Baker
author_facet	Seong Beom Ahn Abidali Mohamedali Charles Chan Julie Fletcher Sun Young Kwun Candice Clarke Owen F Dent Pierre H Chapuis Edouard Nice Mark S Baker
author_sort	Seong Beom Ahn
title	Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
title_short	Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
title_full	Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
title_fullStr	Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
title_full_unstemmed	Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.
title_sort	correlations between integrin ανβ6 expression and clinico-pathological features in stage b and stage c rectal cancer.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/65a42582e5fe46279181117d3f911493
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Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.

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