Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus
Abstract The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children &...
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Nature Portfolio
2017
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oai:doaj.org-article:65ab99682bec4cce975aaf2fc5f6701e2021-12-02T15:05:34ZAcute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus10.1038/s41598-017-09006-62045-2322https://doaj.org/article/65ab99682bec4cce975aaf2fc5f6701e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09006-6https://doaj.org/toc/2045-2322Abstract The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD® kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time.Van Hoan NguyenAudrey Dubot-PérèsFiona M. RussellDavid A. B. DanceKeoudomphone VilivongSouphatsone PhommachanChanthaphone SyladethJana LaiRuth LimMelinda MorpethMayfong MayxayPaul N. NewtonHervé RichetXavier De LamballerieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q Van Hoan Nguyen Audrey Dubot-Pérès Fiona M. Russell David A. B. Dance Keoudomphone Vilivong Souphatsone Phommachan Chanthaphone Syladeth Jana Lai Ruth Lim Melinda Morpeth Mayfong Mayxay Paul N. Newton Hervé Richet Xavier De Lamballerie Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| description |
Abstract The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD® kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time. |
| format |
article |
| author |
Van Hoan Nguyen Audrey Dubot-Pérès Fiona M. Russell David A. B. Dance Keoudomphone Vilivong Souphatsone Phommachan Chanthaphone Syladeth Jana Lai Ruth Lim Melinda Morpeth Mayfong Mayxay Paul N. Newton Hervé Richet Xavier De Lamballerie |
| author_facet |
Van Hoan Nguyen Audrey Dubot-Pérès Fiona M. Russell David A. B. Dance Keoudomphone Vilivong Souphatsone Phommachan Chanthaphone Syladeth Jana Lai Ruth Lim Melinda Morpeth Mayfong Mayxay Paul N. Newton Hervé Richet Xavier De Lamballerie |
| author_sort |
Van Hoan Nguyen |
| title |
Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| title_short |
Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| title_full |
Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| title_fullStr |
Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| title_full_unstemmed |
Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus |
| title_sort |
acute respiratory infections in hospitalized children in vientiane, lao pdr – the importance of respiratory syncytial virus |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/65ab99682bec4cce975aaf2fc5f6701e |
| work_keys_str_mv |
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