Relationship between periodontitis and pre-eclampsia: a meta-analysis.

<h4>Background</h4>Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue.<h4>Methods</h4>A literature search of electronic databases w...

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Auteurs principaux:	Fabrizio Sgolastra, Ambra Petrucci, Marco Severino, Roberto Gatto, Annalisa Monaco
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2013
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/65acd3042d3b4fd68d081fd946817021
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spelling	oai:doaj.org-article:65acd3042d3b4fd68d081fd9468170212021-11-18T08:58:54ZRelationship between periodontitis and pre-eclampsia: a meta-analysis.1932-620310.1371/journal.pone.0071387https://doaj.org/article/65acd3042d3b4fd68d081fd9468170212013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23990948/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue.<h4>Methods</h4>A literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ(2)-based Cochran Q test and I(2) statistic. The level of significance was set at P <0.05.<h4>Results</h4>Fifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38-3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ(2) = 62.42, P<0.00001, I(2) = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups.<h4>Conclusion</h4>Based on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis.Fabrizio SgolastraAmbra PetrucciMarco SeverinoRoberto GattoAnnalisa MonacoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71387 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabrizio Sgolastra Ambra Petrucci Marco Severino Roberto Gatto Annalisa Monaco Relationship between periodontitis and pre-eclampsia: a meta-analysis.
description	<h4>Background</h4>Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue.<h4>Methods</h4>A literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ(2)-based Cochran Q test and I(2) statistic. The level of significance was set at P <0.05.<h4>Results</h4>Fifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38-3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ(2) = 62.42, P<0.00001, I(2) = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups.<h4>Conclusion</h4>Based on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis.
format	article
author	Fabrizio Sgolastra Ambra Petrucci Marco Severino Roberto Gatto Annalisa Monaco
author_facet	Fabrizio Sgolastra Ambra Petrucci Marco Severino Roberto Gatto Annalisa Monaco
author_sort	Fabrizio Sgolastra
title	Relationship between periodontitis and pre-eclampsia: a meta-analysis.
title_short	Relationship between periodontitis and pre-eclampsia: a meta-analysis.
title_full	Relationship between periodontitis and pre-eclampsia: a meta-analysis.
title_fullStr	Relationship between periodontitis and pre-eclampsia: a meta-analysis.
title_full_unstemmed	Relationship between periodontitis and pre-eclampsia: a meta-analysis.
title_sort	relationship between periodontitis and pre-eclampsia: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/65acd3042d3b4fd68d081fd946817021
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Relationship between periodontitis and pre-eclampsia: a meta-analysis.

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