The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.

<h4>Background</h4>Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unkno...

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Autores principales:	Christian Jansen, Hannah Eischeid, Jan Goertzen, Robert Schierwagen, Evrim Anadol, Christian P Strassburg, Tilman Sauerbruch, Margarete Odenthal, Jonel Trebicka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65ad1435f5e54d9385d8297e8c3ead25
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spelling	oai:doaj.org-article:65ad1435f5e54d9385d8297e8c3ead252021-11-25T06:06:58ZThe role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.1932-620310.1371/journal.pone.0103779https://doaj.org/article/65ad1435f5e54d9385d8297e8c3ead252014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25068403/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension.<h4>Methods</h4>We included 60 cirrhotic patients receiving TIPS for prevention of rebleeding and/or therapy-refractory ascites. miRNA-34a levels were measured using qPCR and normalized by SV-40 in the portal and hepatic venous blood of these patients taken at TIPS procedure. Hemodynamic and clinical parameters were assessed before TIPS and during follow-up.<h4>Results</h4>Levels of miRNA-34a were higher in the hepatic vein than in the portal vein. Circulating miRNA-34a in the hepatic vein correlated with ALT, CHE and sodium excretion after TIPS. miRNA-34a showed no correlation with portal pressure, but its levels in the portal vein correlated inversely with the congestion index. Interestingly, the levels of miRNA-34a in the portal and hepatic vein showed inverse correlation with arterial pressure. Furthermore, levels of miRNA-34a in the hepatic vein had a predictive value for survival, but MELD, creatinine at short-time follow-up 14 days after TIPS-insertion and portal pressure after TIPS performed better.<h4>Conclusion</h4>This study demonstrates for the first time, that miRNA-34a may originate to a large extent from the liver. Even though higher levels of miRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better.Christian JansenHannah EischeidJan GoertzenRobert SchierwagenEvrim AnadolChristian P StrassburgTilman SauerbruchMargarete OdenthalJonel TrebickaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e103779 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Jansen Hannah Eischeid Jan Goertzen Robert Schierwagen Evrim Anadol Christian P Strassburg Tilman Sauerbruch Margarete Odenthal Jonel Trebicka The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
description	<h4>Background</h4>Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal hypertension.<h4>Methods</h4>We included 60 cirrhotic patients receiving TIPS for prevention of rebleeding and/or therapy-refractory ascites. miRNA-34a levels were measured using qPCR and normalized by SV-40 in the portal and hepatic venous blood of these patients taken at TIPS procedure. Hemodynamic and clinical parameters were assessed before TIPS and during follow-up.<h4>Results</h4>Levels of miRNA-34a were higher in the hepatic vein than in the portal vein. Circulating miRNA-34a in the hepatic vein correlated with ALT, CHE and sodium excretion after TIPS. miRNA-34a showed no correlation with portal pressure, but its levels in the portal vein correlated inversely with the congestion index. Interestingly, the levels of miRNA-34a in the portal and hepatic vein showed inverse correlation with arterial pressure. Furthermore, levels of miRNA-34a in the hepatic vein had a predictive value for survival, but MELD, creatinine at short-time follow-up 14 days after TIPS-insertion and portal pressure after TIPS performed better.<h4>Conclusion</h4>This study demonstrates for the first time, that miRNA-34a may originate to a large extent from the liver. Even though higher levels of miRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better.
format	article
author	Christian Jansen Hannah Eischeid Jan Goertzen Robert Schierwagen Evrim Anadol Christian P Strassburg Tilman Sauerbruch Margarete Odenthal Jonel Trebicka
author_facet	Christian Jansen Hannah Eischeid Jan Goertzen Robert Schierwagen Evrim Anadol Christian P Strassburg Tilman Sauerbruch Margarete Odenthal Jonel Trebicka
author_sort	Christian Jansen
title	The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
title_short	The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
title_full	The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
title_fullStr	The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
title_full_unstemmed	The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.
title_sort	role of mirna-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving tips.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/65ad1435f5e54d9385d8297e8c3ead25
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The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.

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