Precision multidimensional assay for high-throughput microRNA drug discovery

Progress in drug discovery can be hampered by a limited exploration of chemical space and the difficulty in assessing the full range of drug candidates’ effects on living cells. Here the authors describe a cell-based assay to distinguish between off-target and specific effects of candidate compounds...

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Autores principales:	Benjamin Haefliger, Laura Prochazka, Bartolomeo Angelici, Yaakov Benenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65aee4710469475e974f5ac63c44d69a
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id	oai:doaj.org-article:65aee4710469475e974f5ac63c44d69a
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spelling	oai:doaj.org-article:65aee4710469475e974f5ac63c44d69a2021-12-02T14:39:13ZPrecision multidimensional assay for high-throughput microRNA drug discovery10.1038/ncomms107092041-1723https://doaj.org/article/65aee4710469475e974f5ac63c44d69a2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10709https://doaj.org/toc/2041-1723Progress in drug discovery can be hampered by a limited exploration of chemical space and the difficulty in assessing the full range of drug candidates’ effects on living cells. Here the authors describe a cell-based assay to distinguish between off-target and specific effects of candidate compounds targeting micro RNAs.Benjamin HaefligerLaura ProchazkaBartolomeo AngeliciYaakov BenensonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Haefliger Laura Prochazka Bartolomeo Angelici Yaakov Benenson Precision multidimensional assay for high-throughput microRNA drug discovery
description	Progress in drug discovery can be hampered by a limited exploration of chemical space and the difficulty in assessing the full range of drug candidates’ effects on living cells. Here the authors describe a cell-based assay to distinguish between off-target and specific effects of candidate compounds targeting micro RNAs.
format	article
author	Benjamin Haefliger Laura Prochazka Bartolomeo Angelici Yaakov Benenson
author_facet	Benjamin Haefliger Laura Prochazka Bartolomeo Angelici Yaakov Benenson
author_sort	Benjamin Haefliger
title	Precision multidimensional assay for high-throughput microRNA drug discovery
title_short	Precision multidimensional assay for high-throughput microRNA drug discovery
title_full	Precision multidimensional assay for high-throughput microRNA drug discovery
title_fullStr	Precision multidimensional assay for high-throughput microRNA drug discovery
title_full_unstemmed	Precision multidimensional assay for high-throughput microRNA drug discovery
title_sort	precision multidimensional assay for high-throughput microrna drug discovery
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/65aee4710469475e974f5ac63c44d69a
work_keys_str_mv	AT benjaminhaefliger precisionmultidimensionalassayforhighthroughputmicrornadrugdiscovery AT lauraprochazka precisionmultidimensionalassayforhighthroughputmicrornadrugdiscovery AT bartolomeoangelici precisionmultidimensionalassayforhighthroughputmicrornadrugdiscovery AT yaakovbenenson precisionmultidimensionalassayforhighthroughputmicrornadrugdiscovery
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Precision multidimensional assay for high-throughput microRNA drug discovery

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