TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.

TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.

<h4>Aims</h4>We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical ana...

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Main Authors: Antonius J N M Bastiaansen, Jacco C Karper, Anouk Wezel, Hetty C de Boer, Sabine M J Welten, Rob C M de Jong, Erna A B Peters, Margreet R de Vries, Annemarie M van Oeveren-Rietdijk, Anton Jan van Zonneveld, Jaap F Hamming, A Yaël Nossent, Paul H A Quax
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/65af4eb8c5d64c42a1a40f906225c2e5
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