Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activation by cytoskeletal force.

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Detalles Bibliográficos
Autores principales:	Pontus Nordenfelt, Travis I. Moore, Shalin B. Mehta, Joseph Mathew Kalappurakkal, Vinay Swaminathan, Nobuyasu Koga, Talley J. Lambert, David Baker, Jennifer C. Waters, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Clare M. Waterman, Timothy A. Springer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65af52fbf47f4fb78c2fab61b95611df
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spelling	oai:doaj.org-article:65af52fbf47f4fb78c2fab61b95611df2021-12-02T17:01:19ZDirection of actin flow dictates integrin LFA-1 orientation during leukocyte migration10.1038/s41467-017-01848-y2041-1723https://doaj.org/article/65af52fbf47f4fb78c2fab61b95611df2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01848-yhttps://doaj.org/toc/2041-1723Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activation by cytoskeletal force.Pontus NordenfeltTravis I. MooreShalin B. MehtaJoseph Mathew KalappurakkalVinay SwaminathanNobuyasu KogaTalley J. LambertDavid BakerJennifer C. WatersRudolf OldenbourgTomomi TaniSatyajit MayorClare M. WatermanTimothy A. SpringerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pontus Nordenfelt Travis I. Moore Shalin B. Mehta Joseph Mathew Kalappurakkal Vinay Swaminathan Nobuyasu Koga Talley J. Lambert David Baker Jennifer C. Waters Rudolf Oldenbourg Tomomi Tani Satyajit Mayor Clare M. Waterman Timothy A. Springer Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
description	Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activation by cytoskeletal force.
format	article
author	Pontus Nordenfelt Travis I. Moore Shalin B. Mehta Joseph Mathew Kalappurakkal Vinay Swaminathan Nobuyasu Koga Talley J. Lambert David Baker Jennifer C. Waters Rudolf Oldenbourg Tomomi Tani Satyajit Mayor Clare M. Waterman Timothy A. Springer
author_facet	Pontus Nordenfelt Travis I. Moore Shalin B. Mehta Joseph Mathew Kalappurakkal Vinay Swaminathan Nobuyasu Koga Talley J. Lambert David Baker Jennifer C. Waters Rudolf Oldenbourg Tomomi Tani Satyajit Mayor Clare M. Waterman Timothy A. Springer
author_sort	Pontus Nordenfelt
title	Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
title_short	Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
title_full	Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
title_fullStr	Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
title_full_unstemmed	Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
title_sort	direction of actin flow dictates integrin lfa-1 orientation during leukocyte migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65af52fbf47f4fb78c2fab61b95611df
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Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

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