ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE

The aim of this work was to study features of gene expression TLR2, TLR4, and TLR9 in the course of acute respiratory infection, depending on the time elapsing since the contamination, and dose of infection. The studies of in vivo models of acute respiratory infections caused by Gram-negative Klebsi...

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Autores principales:	E. V. Budanova, O. A. Svitich, E. A. Shulenina, V. V. Zverev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	innate immunity toll-like receptors (tlr) pneumoniae klebsiella pneumonia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/65b105583923493bb0849c77908d1810
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spelling	oai:doaj.org-article:65b105583923493bb0849c77908d18102021-11-18T08:03:47ZASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE1563-06252313-741X10.15789/1563-0625-2018-3-425-430https://doaj.org/article/65b105583923493bb0849c77908d18102018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1530https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this work was to study features of gene expression TLR2, TLR4, and TLR9 in the course of acute respiratory infection, depending on the time elapsing since the contamination, and dose of infection. The studies of in vivo models of acute respiratory infections caused by Gram-negative Klebsiella pneumoniae showed that, at infection dose of 104 CFU/ml, the TLR4 gene expression levels in epithelium of upper respiratory tract at 1, 3, 10 days were increased 30 times and more, complete elimination of the pathogen was observed at 3 days. At the dose of infection of 107 CFU/ml, persistence of the pathogen in upper respiratory tract was observed within a few days, accompanied by a significant increase in the level of TLR9 expression in epithelium of upper respiratory tract, and TLR4 levels in the lungs 1 day after infection, in parallel to elimination of the pathogen from the lower respiratory tract. Thus, the characteristic features of TLR4 and TLR9 gene expression in the upper respiratory tract may be considered a potential diagnostic and prognostic factors in evaluation of the course of acute respiratory infections caused by Klebsiella pneumoniae.E. V. BudanovaO. A. SvitichE. A. ShuleninaV. V. ZverevSPb RAACIarticleinnate immunitytoll-like receptors (tlr)pneumoniaeklebsiella pneumoniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 3, Pp 425-430 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	innate immunity toll-like receptors (tlr) pneumoniae klebsiella pneumonia Immunologic diseases. Allergy RC581-607
spellingShingle	innate immunity toll-like receptors (tlr) pneumoniae klebsiella pneumonia Immunologic diseases. Allergy RC581-607 E. V. Budanova O. A. Svitich E. A. Shulenina V. V. Zverev ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
description	The aim of this work was to study features of gene expression TLR2, TLR4, and TLR9 in the course of acute respiratory infection, depending on the time elapsing since the contamination, and dose of infection. The studies of in vivo models of acute respiratory infections caused by Gram-negative Klebsiella pneumoniae showed that, at infection dose of 104 CFU/ml, the TLR4 gene expression levels in epithelium of upper respiratory tract at 1, 3, 10 days were increased 30 times and more, complete elimination of the pathogen was observed at 3 days. At the dose of infection of 107 CFU/ml, persistence of the pathogen in upper respiratory tract was observed within a few days, accompanied by a significant increase in the level of TLR9 expression in epithelium of upper respiratory tract, and TLR4 levels in the lungs 1 day after infection, in parallel to elimination of the pathogen from the lower respiratory tract. Thus, the characteristic features of TLR4 and TLR9 gene expression in the upper respiratory tract may be considered a potential diagnostic and prognostic factors in evaluation of the course of acute respiratory infections caused by Klebsiella pneumoniae.
format	article
author	E. V. Budanova O. A. Svitich E. A. Shulenina V. V. Zverev
author_facet	E. V. Budanova O. A. Svitich E. A. Shulenina V. V. Zverev
author_sort	E. V. Budanova
title	ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
title_short	ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
title_full	ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
title_fullStr	ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
title_full_unstemmed	ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE
title_sort	association of tlr2, tlr4, tlr9 gene expression related to innate immunity with in vivo acute respiratory infections caused by klebsiella pneumoniae
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/65b105583923493bb0849c77908d1810
work_keys_str_mv	AT evbudanova associationoftlr2tlr4tlr9geneexpressionrelatedtoinnateimmunitywithinvivoacuterespiratoryinfectionscausedbyklebsiellapneumoniae AT oasvitich associationoftlr2tlr4tlr9geneexpressionrelatedtoinnateimmunitywithinvivoacuterespiratoryinfectionscausedbyklebsiellapneumoniae AT eashulenina associationoftlr2tlr4tlr9geneexpressionrelatedtoinnateimmunitywithinvivoacuterespiratoryinfectionscausedbyklebsiellapneumoniae AT vvzverev associationoftlr2tlr4tlr9geneexpressionrelatedtoinnateimmunitywithinvivoacuterespiratoryinfectionscausedbyklebsiellapneumoniae
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ASSOCIATION OF TLR2, TLR4, TLR9 GENE EXPRESSION RELATED TO INNATE IMMUNITY WITH IN VIVO ACUTE RESPIRATORY INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE

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