Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology

Background: The incidence of nodular melanoma (NM) has been consistently described as at least 10-15% of total melanomas for over 15 years despite advances in diagnostic algorithms and medical technology. NMs are strongly correlated with faster rates of growth and poorer prognosis and thus provide...

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Autores principales:	Cliff Rosendahl, Matthew Hishon, Alan Cameron, Sarah Barksdale, David Weedon, Harald Kittler
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2014
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/65b2540cd81f4071b3135a74e79e4e93
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spelling	oai:doaj.org-article:65b2540cd81f4071b3135a74e79e4e932021-11-17T08:32:11ZNodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology10.5826/dpc.0402a152160-9381https://doaj.org/article/65b2540cd81f4071b3135a74e79e4e932014-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/896https://doaj.org/toc/2160-9381 Background: The incidence of nodular melanoma (NM) has been consistently described as at least 10-15% of total melanomas for over 15 years despite advances in diagnostic algorithms and medical technology. NMs are strongly correlated with faster rates of growth and poorer prognosis and thus provide clinicians with a challenge for early recognition. Objective: To evaluate diagnostic clues of consecutive histopathologically proven NMs in one general practice with particular emphasis on dermatoscopic characteristics and compare this to the published literature. Method: A retrospective observational study was performed of five consecutive histologically proven NM, from a total of 212 consecutive melanomas from a general practice in Brisbane, Queensland, Australia. Dermatoscopic images, both polarized and non-polarized, which appears to be a unique resource, and dermatopathologic slides were available for all lesions. Results: All of the NMs in this series were pigmented although one was hypomelanotic. Two of them were symmetrical. The most highly sensitive clues to NM were gray or blue structures and polarizing-specific white lines. Limitations: Due to the small number of NMs in this report no statistical significance can be attributed to the observational findings. Conclusion: This small series supports what is already known: that a significant proportion of NMs may be dermatoscopically symmetrical but that known clues to melanoma are frequently present.Nodular lesions, pigmented or non-pigmented, should be excised to exclude NM if there is any clue to malignancy, regardless of symmetry, unless a confident specific benign diagnosis can be made. Cliff RosendahlMatthew HishonAlan CameronSarah BarksdaleDavid WeedonHarald KittlerMattioli1885articleDermatologyRL1-803ENDermatology Practical & Conceptual (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Cliff Rosendahl Matthew Hishon Alan Cameron Sarah Barksdale David Weedon Harald Kittler Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
description	Background: The incidence of nodular melanoma (NM) has been consistently described as at least 10-15% of total melanomas for over 15 years despite advances in diagnostic algorithms and medical technology. NMs are strongly correlated with faster rates of growth and poorer prognosis and thus provide clinicians with a challenge for early recognition. Objective: To evaluate diagnostic clues of consecutive histopathologically proven NMs in one general practice with particular emphasis on dermatoscopic characteristics and compare this to the published literature. Method: A retrospective observational study was performed of five consecutive histologically proven NM, from a total of 212 consecutive melanomas from a general practice in Brisbane, Queensland, Australia. Dermatoscopic images, both polarized and non-polarized, which appears to be a unique resource, and dermatopathologic slides were available for all lesions. Results: All of the NMs in this series were pigmented although one was hypomelanotic. Two of them were symmetrical. The most highly sensitive clues to NM were gray or blue structures and polarizing-specific white lines. Limitations: Due to the small number of NMs in this report no statistical significance can be attributed to the observational findings. Conclusion: This small series supports what is already known: that a significant proportion of NMs may be dermatoscopically symmetrical but that known clues to melanoma are frequently present.Nodular lesions, pigmented or non-pigmented, should be excised to exclude NM if there is any clue to malignancy, regardless of symmetry, unless a confident specific benign diagnosis can be made.
format	article
author	Cliff Rosendahl Matthew Hishon Alan Cameron Sarah Barksdale David Weedon Harald Kittler
author_facet	Cliff Rosendahl Matthew Hishon Alan Cameron Sarah Barksdale David Weedon Harald Kittler
author_sort	Cliff Rosendahl
title	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
title_short	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
title_full	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
title_fullStr	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
title_full_unstemmed	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
title_sort	nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology
publisher	Mattioli1885
publishDate	2014
url	https://doaj.org/article/65b2540cd81f4071b3135a74e79e4e93
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Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology

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