The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures

Ling Tang,1 Jie-Ru Chen2 1Department of Clinical Laboratory, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of China; 2Department of Paediatrics, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’...

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Autores principales:	Tang L, Chen JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ebrile seizures hemocytes platelet count mean platelet volume platelet distribution width Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/65b27622ef294dc086625f2155b701a3
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spelling	oai:doaj.org-article:65b27622ef294dc086625f2155b701a32021-12-02T17:13:57ZThe Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures1178-7031https://doaj.org/article/65b27622ef294dc086625f2155b701a32021-10-01T00:00:00Zhttps://www.dovepress.com/the-predictive-value-of-hemocytometry-based-on-peripheral-platelet-rel-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Ling Tang,1 Jie-Ru Chen2 1Department of Clinical Laboratory, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of China; 2Department of Paediatrics, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of ChinaCorrespondence: Jie-Ru ChenDepartment of Paediatrics, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of ChinaTel +86 13057386807Email chenjieru_dr@outlook.comObjective: To evaluate the outcome of platelet-related parameters in children with febrile seizures (FSs) and seek low-cost markers for the clinical prediction of FSs.Methods: A total of 79 patients with FSs (the FS group) who were hospitalized in our hospital were selected. Eighty-two patients with fever and without seizures (the FC group) and 81 healthy patients without fever (the HC group) were selected. The results of whole blood cell analysis were retrospectively analyzed.Results: The results of whole blood cell analysis showed that platelet (PLT) count, mean platelet volume (MPV), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) levels in the FS group were significantly lower than in the FC and HC groups (P < 0.05). The platelet-to-lymphocyte ratio (PLR) in the FS and FC groups was significantly higher than in the HC group (P < 0.05), but there was no statistical difference between the FS and FC groups (P > 0.05). The PLT count in the CFS group was significantly lower than in the SFS group (P < 0.05). The PDW of the CFS group was higher compared with the SFS group (P < 0.05). The PLT count and PLR of the relapsed group were lower than those of the non-relapsed group (P < 0.05). The conducted linear regression analysis showed that MCH, PLT, and MPV were closely related to the occurrence of FSs. The binary logistic model showed that MPV was the most important protective factor related to FSs.Conclusion: PLT and MPV are closely related to the occurrence of FSs. PLT and PDW may be able to serve as simple yet effective laboratory indicators for distinguishing different types of FSs. Low PLR levels could be used to predict the risk of FS recurrence.Keywords: febrile seizures, hemocytes, platelet count, mean platelet volume, platelet distribution widthTang LChen JRDove Medical Pressarticleebrile seizureshemocytesplatelet countmean platelet volumeplatelet distribution widthPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5381-5392 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ebrile seizures hemocytes platelet count mean platelet volume platelet distribution width Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ebrile seizures hemocytes platelet count mean platelet volume platelet distribution width Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Tang L Chen JR The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
description	Ling Tang,1 Jie-Ru Chen2 1Department of Clinical Laboratory, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of China; 2Department of Paediatrics, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of ChinaCorrespondence: Jie-Ru ChenDepartment of Paediatrics, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214001, People’s Republic of ChinaTel +86 13057386807Email chenjieru_dr@outlook.comObjective: To evaluate the outcome of platelet-related parameters in children with febrile seizures (FSs) and seek low-cost markers for the clinical prediction of FSs.Methods: A total of 79 patients with FSs (the FS group) who were hospitalized in our hospital were selected. Eighty-two patients with fever and without seizures (the FC group) and 81 healthy patients without fever (the HC group) were selected. The results of whole blood cell analysis were retrospectively analyzed.Results: The results of whole blood cell analysis showed that platelet (PLT) count, mean platelet volume (MPV), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) levels in the FS group were significantly lower than in the FC and HC groups (P < 0.05). The platelet-to-lymphocyte ratio (PLR) in the FS and FC groups was significantly higher than in the HC group (P < 0.05), but there was no statistical difference between the FS and FC groups (P > 0.05). The PLT count in the CFS group was significantly lower than in the SFS group (P < 0.05). The PDW of the CFS group was higher compared with the SFS group (P < 0.05). The PLT count and PLR of the relapsed group were lower than those of the non-relapsed group (P < 0.05). The conducted linear regression analysis showed that MCH, PLT, and MPV were closely related to the occurrence of FSs. The binary logistic model showed that MPV was the most important protective factor related to FSs.Conclusion: PLT and MPV are closely related to the occurrence of FSs. PLT and PDW may be able to serve as simple yet effective laboratory indicators for distinguishing different types of FSs. Low PLR levels could be used to predict the risk of FS recurrence.Keywords: febrile seizures, hemocytes, platelet count, mean platelet volume, platelet distribution width
format	article
author	Tang L Chen JR
author_facet	Tang L Chen JR
author_sort	Tang L
title	The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
title_short	The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
title_full	The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
title_fullStr	The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
title_full_unstemmed	The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
title_sort	predictive value of hemocytometry based on peripheral platelet-related parameters in identifying the causes of febrile seizures
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/65b27622ef294dc086625f2155b701a3
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The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures

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