Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype.
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Nature Portfolio
2021
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oai:doaj.org-article:65b689f6ed0042b1ab0807dd0eb2f0de2021-12-02T14:06:22ZIntegrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma10.1038/s41467-021-21068-92041-1723https://doaj.org/article/65b689f6ed0042b1ab0807dd0eb2f0de2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21068-9https://doaj.org/toc/2041-1723Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype.Ziad BakounyDavid A. BraunSachet A. ShuklaWenting PanXin GaoYue HouAbdallah FlaifelStephen TangAlice Bosma-MoodyMeng Xiao HeNatalie VokesJackson NymanWanling XieAmin H. NassarSarah Abou AlaiwiRonan FlippotGabrielle BouchardJohn A. SteinharterPier Vitale NuzzoMiriam FicialMiriam Sant’AngeloJuliet FormanJacob E. BerchuckShaan DudaniKevin BiJihye ParkSabrina CampMaura Sticco-IvinsLaure HirschSylvan C. BacaMegan Wind-RotoloPetra Ross-MacdonaldMaxine SunGwo-Shu Mary LeeSteven L. ChangXiao X. WeiBradley A. McGregorLauren C. HarshmanGiannicola GenoveseLeigh EllisMark PomerantzMichelle S. HirschMatthew L. FreedmanMichael B. AtkinsCatherine J. WuThai H. HoW. Marston LinehanDavid F. McDermottDaniel Y. C. HengSrinivas R. ViswanathanSabina SignorettiEliezer M. Van AllenToni K. ChoueiriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
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Science Q Ziad Bakouny David A. Braun Sachet A. Shukla Wenting Pan Xin Gao Yue Hou Abdallah Flaifel Stephen Tang Alice Bosma-Moody Meng Xiao He Natalie Vokes Jackson Nyman Wanling Xie Amin H. Nassar Sarah Abou Alaiwi Ronan Flippot Gabrielle Bouchard John A. Steinharter Pier Vitale Nuzzo Miriam Ficial Miriam Sant’Angelo Juliet Forman Jacob E. Berchuck Shaan Dudani Kevin Bi Jihye Park Sabrina Camp Maura Sticco-Ivins Laure Hirsch Sylvan C. Baca Megan Wind-Rotolo Petra Ross-Macdonald Maxine Sun Gwo-Shu Mary Lee Steven L. Chang Xiao X. Wei Bradley A. McGregor Lauren C. Harshman Giannicola Genovese Leigh Ellis Mark Pomerantz Michelle S. Hirsch Matthew L. Freedman Michael B. Atkins Catherine J. Wu Thai H. Ho W. Marston Linehan David F. McDermott Daniel Y. C. Heng Srinivas R. Viswanathan Sabina Signoretti Eliezer M. Van Allen Toni K. Choueiri Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| description |
Sarcomatoid and rhabdoid tumours are highly aggressive forms of renal cell carcinoma that are also responsive to immunotherapy. In this study, the authors perform a comprehensive molecular characterization of these tumours discovering an enrichment of specific alterations and an inflamed phenotype. |
| format |
article |
| author |
Ziad Bakouny David A. Braun Sachet A. Shukla Wenting Pan Xin Gao Yue Hou Abdallah Flaifel Stephen Tang Alice Bosma-Moody Meng Xiao He Natalie Vokes Jackson Nyman Wanling Xie Amin H. Nassar Sarah Abou Alaiwi Ronan Flippot Gabrielle Bouchard John A. Steinharter Pier Vitale Nuzzo Miriam Ficial Miriam Sant’Angelo Juliet Forman Jacob E. Berchuck Shaan Dudani Kevin Bi Jihye Park Sabrina Camp Maura Sticco-Ivins Laure Hirsch Sylvan C. Baca Megan Wind-Rotolo Petra Ross-Macdonald Maxine Sun Gwo-Shu Mary Lee Steven L. Chang Xiao X. Wei Bradley A. McGregor Lauren C. Harshman Giannicola Genovese Leigh Ellis Mark Pomerantz Michelle S. Hirsch Matthew L. Freedman Michael B. Atkins Catherine J. Wu Thai H. Ho W. Marston Linehan David F. McDermott Daniel Y. C. Heng Srinivas R. Viswanathan Sabina Signoretti Eliezer M. Van Allen Toni K. Choueiri |
| author_facet |
Ziad Bakouny David A. Braun Sachet A. Shukla Wenting Pan Xin Gao Yue Hou Abdallah Flaifel Stephen Tang Alice Bosma-Moody Meng Xiao He Natalie Vokes Jackson Nyman Wanling Xie Amin H. Nassar Sarah Abou Alaiwi Ronan Flippot Gabrielle Bouchard John A. Steinharter Pier Vitale Nuzzo Miriam Ficial Miriam Sant’Angelo Juliet Forman Jacob E. Berchuck Shaan Dudani Kevin Bi Jihye Park Sabrina Camp Maura Sticco-Ivins Laure Hirsch Sylvan C. Baca Megan Wind-Rotolo Petra Ross-Macdonald Maxine Sun Gwo-Shu Mary Lee Steven L. Chang Xiao X. Wei Bradley A. McGregor Lauren C. Harshman Giannicola Genovese Leigh Ellis Mark Pomerantz Michelle S. Hirsch Matthew L. Freedman Michael B. Atkins Catherine J. Wu Thai H. Ho W. Marston Linehan David F. McDermott Daniel Y. C. Heng Srinivas R. Viswanathan Sabina Signoretti Eliezer M. Van Allen Toni K. Choueiri |
| author_sort |
Ziad Bakouny |
| title |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| title_short |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| title_full |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| title_fullStr |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| title_full_unstemmed |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| title_sort |
integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/65b689f6ed0042b1ab0807dd0eb2f0de |
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