MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA

We studied blood contents of alpha-2-macroglobulin (α2-MG), pregnancy-associated alpha2-glycoprotein (PAG), and their immune complexes with IgG in healthy female controls, as well as in women with adenomyosis, females with uterine myoma (with or without proliferation), and in cases of a leiomyoma co...

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Autores principales:	V. N. Zorina, S. V. Shramko, R. M. Zorina, L. G. Bazhenova, N. V. Promzeleva, N. A. Zorin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	alpha-2-macroglobulin pregnancy associated alpha-2-glycoprotein immune complexes adenomyosis myoma proliferation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/65b8874924ed49fd922ea0b2a3f0646e
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spelling	oai:doaj.org-article:65b8874924ed49fd922ea0b2a3f0646e2021-11-18T08:03:44ZMACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA1563-06252313-741X10.15789/1563-0625-2015-3-287-292https://doaj.org/article/65b8874924ed49fd922ea0b2a3f0646e2015-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/895https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe studied blood contents of alpha-2-macroglobulin (α2-MG), pregnancy-associated alpha2-glycoprotein (PAG), and their immune complexes with IgG in healthy female controls, as well as in women with adenomyosis, females with uterine myoma (with or without proliferation), and in cases of a leiomyoma combined with adenomyosis. We found that the most pronounced reduction in α2-MG concentrations was observed in leiomyoma, but they were not decreased in a combination of myoma/ adenomyosis. The PAG levels, a known proliferation marker, have been shown to be increased only in the combined disorder. The amounts of immune complexes (α2-MG/IgG and PAG-IgG) were more significantly increased in leiomyoma complicated by adenomyosis. Correlative interrelationships between the studied parameters differed between normal and pathological conditions. Given that α2-MG and PAG are immunoregulatory proteins being actively involved in proliferative and inflammatory processes, we may assume that they participate in pathogenesis of immune-related uterine diseases, and, especially, in combined disorders.V. N. ZorinaS. V. ShramkoR. M. ZorinaL. G. BazhenovaN. V. PromzelevaN. A. ZorinSPb RAACIarticlealpha-2-macroglobulinpregnancy associated alpha-2-glycoproteinimmune complexesadenomyosismyomaproliferationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 3, Pp 287-292 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	alpha-2-macroglobulin pregnancy associated alpha-2-glycoprotein immune complexes adenomyosis myoma proliferation Immunologic diseases. Allergy RC581-607
spellingShingle	alpha-2-macroglobulin pregnancy associated alpha-2-glycoprotein immune complexes adenomyosis myoma proliferation Immunologic diseases. Allergy RC581-607 V. N. Zorina S. V. Shramko R. M. Zorina L. G. Bazhenova N. V. Promzeleva N. A. Zorin MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
description	We studied blood contents of alpha-2-macroglobulin (α2-MG), pregnancy-associated alpha2-glycoprotein (PAG), and their immune complexes with IgG in healthy female controls, as well as in women with adenomyosis, females with uterine myoma (with or without proliferation), and in cases of a leiomyoma combined with adenomyosis. We found that the most pronounced reduction in α2-MG concentrations was observed in leiomyoma, but they were not decreased in a combination of myoma/ adenomyosis. The PAG levels, a known proliferation marker, have been shown to be increased only in the combined disorder. The amounts of immune complexes (α2-MG/IgG and PAG-IgG) were more significantly increased in leiomyoma complicated by adenomyosis. Correlative interrelationships between the studied parameters differed between normal and pathological conditions. Given that α2-MG and PAG are immunoregulatory proteins being actively involved in proliferative and inflammatory processes, we may assume that they participate in pathogenesis of immune-related uterine diseases, and, especially, in combined disorders.
format	article
author	V. N. Zorina S. V. Shramko R. M. Zorina L. G. Bazhenova N. V. Promzeleva N. A. Zorin
author_facet	V. N. Zorina S. V. Shramko R. M. Zorina L. G. Bazhenova N. V. Promzeleva N. A. Zorin
author_sort	V. N. Zorina
title	MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
title_short	MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
title_full	MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
title_fullStr	MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
title_full_unstemmed	MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA
title_sort	macroglobulin proteins in adenomyosis and uterine leiomyoma
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/65b8874924ed49fd922ea0b2a3f0646e
work_keys_str_mv	AT vnzorina macroglobulinproteinsinadenomyosisanduterineleiomyoma AT svshramko macroglobulinproteinsinadenomyosisanduterineleiomyoma AT rmzorina macroglobulinproteinsinadenomyosisanduterineleiomyoma AT lgbazhenova macroglobulinproteinsinadenomyosisanduterineleiomyoma AT nvpromzeleva macroglobulinproteinsinadenomyosisanduterineleiomyoma AT nazorin macroglobulinproteinsinadenomyosisanduterineleiomyoma
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MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA

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