Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China

Diagnosis of significant liver fibrosis is essential to facilitate the optimal treatment decisions and improve prognosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the value of inflammatory indicators and construct a nomogram that effectively predicts significant liver fibrosis...

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Autores principales:	Xiujuan Zhang, Yusheng Jie, Zemin Wan, Shanshan Lin, Yingxian Li, Ming Lin, Shuduo Wu, Xiaoju Wu, Meijie Shi, Huanming Xiao, Minling Cao, Jiao Gong, Xiaoling Chi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic hepatitis B inflammatory indicators liver fibrosis diagnosis predicting tool Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/65c1923d17bf4bfab28eea9892736031
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spelling	oai:doaj.org-article:65c1923d17bf4bfab28eea98927360312021-11-10T08:25:14ZPrognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China1663-981210.3389/fphar.2021.653751https://doaj.org/article/65c1923d17bf4bfab28eea98927360312021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.653751/fullhttps://doaj.org/toc/1663-9812Diagnosis of significant liver fibrosis is essential to facilitate the optimal treatment decisions and improve prognosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the value of inflammatory indicators and construct a nomogram that effectively predicts significant liver fibrosis among CHB patients. 563 CHB patients from two centers in China from 2014 to 2019 were divided into three cohorts (development, internal validation, and independent validation cohorts), assigned into cases with significant fibrosis (liver fibrosis stages ≥2) and those without. Multiple biochemical and serological inflammatory indicators were investigated. Inflammatory indicators, Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were significantly associated with significant liver fibrosis in CHB patients but limited predictive performance, and then we combined them with prothrombin time activity percentage (PTA) and liver stiffness measurement (LSM) were identified by multivariate logistic regression analysis. Based on these factors, we constructed the nomogram with excellent performance. The area under the receiver operating characteristic curve (AUROC) for the nomogram in the development, internal validation, and independent validation cohorts were 0.860, 0.877, and 0.811, respectively. Our nomogram based on ALT and AST that had excellent performance in predicting significant fibrosis of CHB patients were constructed.Xiujuan ZhangYusheng JieZemin WanShanshan LinYingxian LiMing LinShuduo WuXiaoju WuMeijie ShiHuanming XiaoMinling CaoJiao GongXiaoling ChiFrontiers Media S.A.articlechronic hepatitis Binflammatory indicatorsliver fibrosisdiagnosispredicting toolTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic hepatitis B inflammatory indicators liver fibrosis diagnosis predicting tool Therapeutics. Pharmacology RM1-950
spellingShingle	chronic hepatitis B inflammatory indicators liver fibrosis diagnosis predicting tool Therapeutics. Pharmacology RM1-950 Xiujuan Zhang Yusheng Jie Zemin Wan Shanshan Lin Yingxian Li Ming Lin Shuduo Wu Xiaoju Wu Meijie Shi Huanming Xiao Minling Cao Jiao Gong Xiaoling Chi Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
description	Diagnosis of significant liver fibrosis is essential to facilitate the optimal treatment decisions and improve prognosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the value of inflammatory indicators and construct a nomogram that effectively predicts significant liver fibrosis among CHB patients. 563 CHB patients from two centers in China from 2014 to 2019 were divided into three cohorts (development, internal validation, and independent validation cohorts), assigned into cases with significant fibrosis (liver fibrosis stages ≥2) and those without. Multiple biochemical and serological inflammatory indicators were investigated. Inflammatory indicators, Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were significantly associated with significant liver fibrosis in CHB patients but limited predictive performance, and then we combined them with prothrombin time activity percentage (PTA) and liver stiffness measurement (LSM) were identified by multivariate logistic regression analysis. Based on these factors, we constructed the nomogram with excellent performance. The area under the receiver operating characteristic curve (AUROC) for the nomogram in the development, internal validation, and independent validation cohorts were 0.860, 0.877, and 0.811, respectively. Our nomogram based on ALT and AST that had excellent performance in predicting significant fibrosis of CHB patients were constructed.
format	article
author	Xiujuan Zhang Yusheng Jie Zemin Wan Shanshan Lin Yingxian Li Ming Lin Shuduo Wu Xiaoju Wu Meijie Shi Huanming Xiao Minling Cao Jiao Gong Xiaoling Chi
author_facet	Xiujuan Zhang Yusheng Jie Zemin Wan Shanshan Lin Yingxian Li Ming Lin Shuduo Wu Xiaoju Wu Meijie Shi Huanming Xiao Minling Cao Jiao Gong Xiaoling Chi
author_sort	Xiujuan Zhang
title	Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
title_short	Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
title_full	Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
title_fullStr	Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
title_full_unstemmed	Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China
title_sort	prognostic value of inflammatory indicators in chronic hepatitis b patients with significant liver fibrosis: a multicenter study in china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/65c1923d17bf4bfab28eea9892736031
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Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China

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