CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.

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Autores principales:	Arnaud P. J. Giese, Yi-Quan Tang, Ghanshyam P. Sinha, Michael R. Bowl, Adam C. Goldring, Andrew Parker, Mary J. Freeman, Steve D. M. Brown, Saima Riazuddin, Robert Fettiplace, William R. Schafer, Gregory I. Frolenkov, Zubair M. Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65c3629626804bdea9661937eb27fcb2
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spelling	oai:doaj.org-article:65c3629626804bdea9661937eb27fcb22021-12-02T13:24:04ZCIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells10.1038/s41467-017-00061-12041-1723https://doaj.org/article/65c3629626804bdea9661937eb27fcb22017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00061-1https://doaj.org/toc/2041-1723Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.Arnaud P. J. GieseYi-Quan TangGhanshyam P. SinhaMichael R. BowlAdam C. GoldringAndrew ParkerMary J. FreemanSteve D. M. BrownSaima RiazuddinRobert FettiplaceWilliam R. SchaferGregory I. FrolenkovZubair M. AhmedNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
description	Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.
format	article
author	Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed
author_facet	Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed
author_sort	Arnaud P. J. Giese
title	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
title_short	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
title_full	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
title_fullStr	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
title_full_unstemmed	CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
title_sort	cib2 interacts with tmc1 and tmc2 and is essential for mechanotransduction in auditory hair cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65c3629626804bdea9661937eb27fcb2
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CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

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