Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients

Xinjie Tu,* Huihua Qiu,* Shasha Lin, Weilei He, Guiqian Huang, Xingru Zhang, Yuemin Wu, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Purpose: Population-based studies have reve...

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Autores principales:	Tu X, Qiu H, Lin S, He W, Huang G, Zhang X, Wu Y, He J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Serum magnesium Cognitive impairment Stroke Risk Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/65c9af5d3143480dac383ca0993e2f91
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spelling	oai:doaj.org-article:65c9af5d3143480dac383ca0993e2f912021-12-02T07:05:54ZLow levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients1178-2021https://doaj.org/article/65c9af5d3143480dac383ca0993e2f912018-11-01T00:00:00Zhttps://www.dovepress.com/low-levels-of-serum-magnesium-are-associated-with-poststroke-cognitive-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xinjie Tu,* Huihua Qiu,* Shasha Lin, Weilei He, Guiqian Huang, Xingru Zhang, Yuemin Wu, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Purpose: Population-based studies have revealed a high prevalence of cognitive impairment after stroke. We aimed to determine the impact of serum magnesium (Mg2+) levels on the occurrence of poststroke cognitive impairment (PSCI).Patients and methods: Acute ischemic stroke patients (n = 327) were enrolled in our study and serum Mg2+ levels were assessed on admission. The cognitive performance of each patient was evaluated using the Mini–Mental State Examination (MMSE) at a 1-month follow-up visit.Results: One hundred five (32.1%) patients were diagnosed with PSCI at 1-month poststroke. The serum Mg2+ levels in both the PSCI group and the non-PSCI group were significantly lower than those in normal control group (P<0.001). In addition, the PSCI group had lower levels of serum Mg2+ compared to the non-PSCI group (P=0.003). In the binary logistic regression analysis, a serum Mg2+ level of ≤0.82 mmol/L was significantly associated with an increased risk of developing PSCI by the 1-month follow-up (OR 2.236, 95% CI 1.232–4.058, P=0.008), as was age (OR 1.043, 95% CI 1.014–1.073, P=0.003).Conclusion: Our results demonstrate the existence of a significant association between low levels of serum Mg2+ and the occurrence of PSCI 1-month poststroke, and these results suggest that low levels of serum Mg2+ on admission may serve as a risk factor for developing PSCI by 1-month poststroke. Keywords: cognition, magnesium, stroke, risk factor Tu XQiu HLin SHe WHuang GZhang XWu YHe JDove Medical PressarticleSerum magnesiumCognitive impairmentStrokeRiskNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2947-2954 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Serum magnesium Cognitive impairment Stroke Risk Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Serum magnesium Cognitive impairment Stroke Risk Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tu X Qiu H Lin S He W Huang G Zhang X Wu Y He J Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
description	Xinjie Tu,* Huihua Qiu,* Shasha Lin, Weilei He, Guiqian Huang, Xingru Zhang, Yuemin Wu, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Purpose: Population-based studies have revealed a high prevalence of cognitive impairment after stroke. We aimed to determine the impact of serum magnesium (Mg2+) levels on the occurrence of poststroke cognitive impairment (PSCI).Patients and methods: Acute ischemic stroke patients (n = 327) were enrolled in our study and serum Mg2+ levels were assessed on admission. The cognitive performance of each patient was evaluated using the Mini–Mental State Examination (MMSE) at a 1-month follow-up visit.Results: One hundred five (32.1%) patients were diagnosed with PSCI at 1-month poststroke. The serum Mg2+ levels in both the PSCI group and the non-PSCI group were significantly lower than those in normal control group (P<0.001). In addition, the PSCI group had lower levels of serum Mg2+ compared to the non-PSCI group (P=0.003). In the binary logistic regression analysis, a serum Mg2+ level of ≤0.82 mmol/L was significantly associated with an increased risk of developing PSCI by the 1-month follow-up (OR 2.236, 95% CI 1.232–4.058, P=0.008), as was age (OR 1.043, 95% CI 1.014–1.073, P=0.003).Conclusion: Our results demonstrate the existence of a significant association between low levels of serum Mg2+ and the occurrence of PSCI 1-month poststroke, and these results suggest that low levels of serum Mg2+ on admission may serve as a risk factor for developing PSCI by 1-month poststroke. Keywords: cognition, magnesium, stroke, risk factor
format	article
author	Tu X Qiu H Lin S He W Huang G Zhang X Wu Y He J
author_facet	Tu X Qiu H Lin S He W Huang G Zhang X Wu Y He J
author_sort	Tu X
title	Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
title_short	Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
title_full	Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
title_fullStr	Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
title_full_unstemmed	Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
title_sort	low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/65c9af5d3143480dac383ca0993e2f91
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Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients

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