Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains

Abstract Purpose To evaluate and determine age‐related changes in rat brains by studying the diffusion kurtosis imaging results among different age groups of rats. Methods Sprague–Dawley (SD) rats underwent conventional magnetic resonance imaging (MRI) and diffusion Kurtosis Imaging (DKI). Two diffu...

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Autores principales:	Xue‐Fang Han, Zuo‐Jun Geng, Qing‐Feng Zhu, Zhen‐Hu Song, Huan‐Di Lv
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	age‐related correlation analysis brain aging diffusion kurtosis imaging magnetic resonance imaging Sprague–Dawley rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/65c9f5d6b6ee46618def811783b1e25b
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spelling	oai:doaj.org-article:65c9f5d6b6ee46618def811783b1e25b2021-11-25T06:06:36ZDiffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains2162-327910.1002/brb3.2136https://doaj.org/article/65c9f5d6b6ee46618def811783b1e25b2021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2136https://doaj.org/toc/2162-3279Abstract Purpose To evaluate and determine age‐related changes in rat brains by studying the diffusion kurtosis imaging results among different age groups of rats. Methods Sprague–Dawley (SD) rats underwent conventional magnetic resonance imaging (MRI) and diffusion Kurtosis Imaging (DKI). Two diffusion values of mean kurtosis (MK) and kurtosis (K⊥) were measured and analyzed based on laterality, brain regions and age groups. The MK and K⊥ data were plotted against different age groups. Results No laterality was found for the MK or K⊥ values in the cerebral cortex (CT), external capsule (EC), or caudate putamen (CPu) regions. In contrast, significant changes in these values were observed among different age groups. Changes of the MK and K⊥ values were significant in both hemispheres in the EC, the CT, and the CPu brain regions. The changes in the MK and K⊥ values showed a parabolic relationship with ages in all the brain regions. Conclusion No laterality in the MK and K⊥ values was observed for the EC, CT, or CPu regions of the rat brain. Significant changes in MK and K⊥ values were both observed among different age groups, thus suggesting diffusion kurtosis imaging as an efficient tool for studying brain aging in rats.Xue‐Fang HanZuo‐Jun GengQing‐Feng ZhuZhen‐Hu SongHuan‐Di LvWileyarticleage‐related correlation analysisbrain agingdiffusion kurtosis imagingmagnetic resonance imagingSprague–Dawley ratNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	age‐related correlation analysis brain aging diffusion kurtosis imaging magnetic resonance imaging Sprague–Dawley rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	age‐related correlation analysis brain aging diffusion kurtosis imaging magnetic resonance imaging Sprague–Dawley rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xue‐Fang Han Zuo‐Jun Geng Qing‐Feng Zhu Zhen‐Hu Song Huan‐Di Lv Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
description	Abstract Purpose To evaluate and determine age‐related changes in rat brains by studying the diffusion kurtosis imaging results among different age groups of rats. Methods Sprague–Dawley (SD) rats underwent conventional magnetic resonance imaging (MRI) and diffusion Kurtosis Imaging (DKI). Two diffusion values of mean kurtosis (MK) and kurtosis (K⊥) were measured and analyzed based on laterality, brain regions and age groups. The MK and K⊥ data were plotted against different age groups. Results No laterality was found for the MK or K⊥ values in the cerebral cortex (CT), external capsule (EC), or caudate putamen (CPu) regions. In contrast, significant changes in these values were observed among different age groups. Changes of the MK and K⊥ values were significant in both hemispheres in the EC, the CT, and the CPu brain regions. The changes in the MK and K⊥ values showed a parabolic relationship with ages in all the brain regions. Conclusion No laterality in the MK and K⊥ values was observed for the EC, CT, or CPu regions of the rat brain. Significant changes in MK and K⊥ values were both observed among different age groups, thus suggesting diffusion kurtosis imaging as an efficient tool for studying brain aging in rats.
format	article
author	Xue‐Fang Han Zuo‐Jun Geng Qing‐Feng Zhu Zhen‐Hu Song Huan‐Di Lv
author_facet	Xue‐Fang Han Zuo‐Jun Geng Qing‐Feng Zhu Zhen‐Hu Song Huan‐Di Lv
author_sort	Xue‐Fang Han
title	Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
title_short	Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
title_full	Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
title_fullStr	Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
title_full_unstemmed	Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains
title_sort	diffusion kurtosis imaging: an efficient tool for evaluating age‐related changes in rat brains
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/65c9f5d6b6ee46618def811783b1e25b
work_keys_str_mv	AT xuefanghan diffusionkurtosisimaginganefficienttoolforevaluatingagerelatedchangesinratbrains AT zuojungeng diffusionkurtosisimaginganefficienttoolforevaluatingagerelatedchangesinratbrains AT qingfengzhu diffusionkurtosisimaginganefficienttoolforevaluatingagerelatedchangesinratbrains AT zhenhusong diffusionkurtosisimaginganefficienttoolforevaluatingagerelatedchangesinratbrains AT huandilv diffusionkurtosisimaginganefficienttoolforevaluatingagerelatedchangesinratbrains
_version_	1718414167026696192

Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains

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