Cancer and Infective Endocarditis: Characteristics and Prognostic Impact

Background: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry.Methods: Three thousand and eighty-five patients with IE were ide...

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Autores principales:	Bernard Cosyns, Bram Roosens, Patrizio Lancellotti, Cécile Laroche, Raluca Dulgheru, Valentina Scheggi, Isidre Vilacosta, Agnès Pasquet, Cornelia Piper, Graciela Reyes, Essam Mahfouz, Zhanna Kobalava, Lionel Piroth, Jarosław D. Kasprzak, Antonella Moreo, Jean-François Faucher, Julien Ternacle, Marwa Meshaal, Aldo P. Maggioni, Bernard Iung, Gilbert Habib
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cancer cardiac surgery infective endocarditis registry valve disease Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/65cb614800264b0697d7f875951daf31
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spelling	oai:doaj.org-article:65cb614800264b0697d7f875951daf312021-11-11T06:26:00ZCancer and Infective Endocarditis: Characteristics and Prognostic Impact2297-055X10.3389/fcvm.2021.766996https://doaj.org/article/65cb614800264b0697d7f875951daf312021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.766996/fullhttps://doaj.org/toc/2297-055XBackground: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry.Methods: Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients.Results: In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were S. aureus (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, P = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, P = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, P = 0.006, and 18.0 vs. 10.2%; P < 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine > 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated).Conclusions: Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.Bernard CosynsBernard CosynsBram RoosensPatrizio LancellottiCécile LarocheRaluca DulgheruValentina ScheggiIsidre VilacostaAgnès PasquetAgnès PasquetCornelia PiperGraciela ReyesEssam MahfouzZhanna KobalavaLionel PirothJarosław D. KasprzakAntonella MoreoJean-François FaucherJulien TernacleJulien TernacleMarwa MeshaalAldo P. MaggioniAldo P. MaggioniBernard IungGilbert HabibGilbert HabibFrontiers Media S.A.articlecancercardiac surgeryinfective endocarditisregistryvalve diseaseDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer cardiac surgery infective endocarditis registry valve disease Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cancer cardiac surgery infective endocarditis registry valve disease Diseases of the circulatory (Cardiovascular) system RC666-701 Bernard Cosyns Bernard Cosyns Bram Roosens Patrizio Lancellotti Cécile Laroche Raluca Dulgheru Valentina Scheggi Isidre Vilacosta Agnès Pasquet Agnès Pasquet Cornelia Piper Graciela Reyes Essam Mahfouz Zhanna Kobalava Lionel Piroth Jarosław D. Kasprzak Antonella Moreo Jean-François Faucher Julien Ternacle Julien Ternacle Marwa Meshaal Aldo P. Maggioni Aldo P. Maggioni Bernard Iung Gilbert Habib Gilbert Habib Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
description	Background: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry.Methods: Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients.Results: In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were S. aureus (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, P = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, P = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, P = 0.006, and 18.0 vs. 10.2%; P < 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine > 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated).Conclusions: Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.
format	article
author	Bernard Cosyns Bernard Cosyns Bram Roosens Patrizio Lancellotti Cécile Laroche Raluca Dulgheru Valentina Scheggi Isidre Vilacosta Agnès Pasquet Agnès Pasquet Cornelia Piper Graciela Reyes Essam Mahfouz Zhanna Kobalava Lionel Piroth Jarosław D. Kasprzak Antonella Moreo Jean-François Faucher Julien Ternacle Julien Ternacle Marwa Meshaal Aldo P. Maggioni Aldo P. Maggioni Bernard Iung Gilbert Habib Gilbert Habib
author_facet	Bernard Cosyns Bernard Cosyns Bram Roosens Patrizio Lancellotti Cécile Laroche Raluca Dulgheru Valentina Scheggi Isidre Vilacosta Agnès Pasquet Agnès Pasquet Cornelia Piper Graciela Reyes Essam Mahfouz Zhanna Kobalava Lionel Piroth Jarosław D. Kasprzak Antonella Moreo Jean-François Faucher Julien Ternacle Julien Ternacle Marwa Meshaal Aldo P. Maggioni Aldo P. Maggioni Bernard Iung Gilbert Habib Gilbert Habib
author_sort	Bernard Cosyns
title	Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
title_short	Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
title_full	Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
title_fullStr	Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
title_full_unstemmed	Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
title_sort	cancer and infective endocarditis: characteristics and prognostic impact
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/65cb614800264b0697d7f875951daf31
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Cancer and Infective Endocarditis: Characteristics and Prognostic Impact

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