The use of polyisobutylene-based polymers in ophthalmology

A novel polyolefin called poly(styrene-block-isobutylene-block-styrene) (“SIBS”) originated from Joseph P. Kennedy's laboratory at the University of Akron (Akron, Ohio, United States) and was developed as a biomaterial for long-term implant applications by the author. SIBS has no cleavable grou...

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Auteur principal:	Leonard Pinchuk
Format:	article
Langue:	EN
Publié:	KeAi Communications Co., Ltd. 2022
Sujets:	Poly(styrene-block-isobutylene-block-styrene) SIBS Glaucoma MicroShunt Intraocular Lens IOL Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/65cf3ac7b5584da2af427225a9280b50
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spelling	oai:doaj.org-article:65cf3ac7b5584da2af427225a9280b502021-11-26T04:37:04ZThe use of polyisobutylene-based polymers in ophthalmology2452-199X10.1016/j.bioactmat.2021.09.005https://doaj.org/article/65cf3ac7b5584da2af427225a9280b502022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004151https://doaj.org/toc/2452-199XA novel polyolefin called poly(styrene-block-isobutylene-block-styrene) (“SIBS”) originated from Joseph P. Kennedy's laboratory at the University of Akron (Akron, Ohio, United States) and was developed as a biomaterial for long-term implant applications by the author. SIBS has no cleavable groups on its backbone or sidechains, is comprised predominantly of alternating secondary and quaternary carbons on its backbone, which prevents embrittlement and cracking under flexion, and undergoes multiple purification steps which renders it extremely biocompatible and well-suited for long-term applications in the eye. This article explores two ophthalmic devices; 1) the PRESERFLO® MicroShunt (Santen Pharmaceutical Co. Ltd., Osaka, Japan) made from SIBS that lowers intraocular pressure to thwart progression of vision loss from glaucoma, and 2) a novel intraocular lens (IOL) made from crosslinked polyisobutylene, which is under-development by Xi'an Eyedeal Medical Technology Co., Ltd. (Xi'an, China) that does not glisten nor cloud over time, as do most conventional IOLs.Leonard PinchukKeAi Communications Co., Ltd.articlePoly(styrene-block-isobutylene-block-styrene)SIBSGlaucomaMicroShuntIntraocular LensIOLMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 185-194 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Poly(styrene-block-isobutylene-block-styrene) SIBS Glaucoma MicroShunt Intraocular Lens IOL Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Poly(styrene-block-isobutylene-block-styrene) SIBS Glaucoma MicroShunt Intraocular Lens IOL Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Leonard Pinchuk The use of polyisobutylene-based polymers in ophthalmology
description	A novel polyolefin called poly(styrene-block-isobutylene-block-styrene) (“SIBS”) originated from Joseph P. Kennedy's laboratory at the University of Akron (Akron, Ohio, United States) and was developed as a biomaterial for long-term implant applications by the author. SIBS has no cleavable groups on its backbone or sidechains, is comprised predominantly of alternating secondary and quaternary carbons on its backbone, which prevents embrittlement and cracking under flexion, and undergoes multiple purification steps which renders it extremely biocompatible and well-suited for long-term applications in the eye. This article explores two ophthalmic devices; 1) the PRESERFLO® MicroShunt (Santen Pharmaceutical Co. Ltd., Osaka, Japan) made from SIBS that lowers intraocular pressure to thwart progression of vision loss from glaucoma, and 2) a novel intraocular lens (IOL) made from crosslinked polyisobutylene, which is under-development by Xi'an Eyedeal Medical Technology Co., Ltd. (Xi'an, China) that does not glisten nor cloud over time, as do most conventional IOLs.
format	article
author	Leonard Pinchuk
author_facet	Leonard Pinchuk
author_sort	Leonard Pinchuk
title	The use of polyisobutylene-based polymers in ophthalmology
title_short	The use of polyisobutylene-based polymers in ophthalmology
title_full	The use of polyisobutylene-based polymers in ophthalmology
title_fullStr	The use of polyisobutylene-based polymers in ophthalmology
title_full_unstemmed	The use of polyisobutylene-based polymers in ophthalmology
title_sort	use of polyisobutylene-based polymers in ophthalmology
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/65cf3ac7b5584da2af427225a9280b50
work_keys_str_mv	AT leonardpinchuk theuseofpolyisobutylenebasedpolymersinophthalmology AT leonardpinchuk useofpolyisobutylenebasedpolymersinophthalmology
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The use of polyisobutylene-based polymers in ophthalmology

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