IL-12 protects from psoriasiform skin inflammation

IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue prote...

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Autores principales:	Paulina Kulig, Stephanie Musiol, Sandra Nicole Freiberger, Bettina Schreiner, Gabor Gyülveszi, Giancarlo Russo, Stanislav Pantelyushin, Kenji Kishihara, Francesca Alessandrini, Thomas Kündig, Federica Sallusto, Günther F.L. Hofbauer, Stefan Haak, Burkhard Becher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65cfea74d59d466a9e896738ae39f149
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spelling	oai:doaj.org-article:65cfea74d59d466a9e896738ae39f1492021-12-02T14:39:13ZIL-12 protects from psoriasiform skin inflammation10.1038/ncomms134662041-1723https://doaj.org/article/65cfea74d59d466a9e896738ae39f1492016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13466https://doaj.org/toc/2041-1723IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin.Paulina KuligStephanie MusiolSandra Nicole FreibergerBettina SchreinerGabor GyülvesziGiancarlo RussoStanislav PantelyushinKenji KishiharaFrancesca AlessandriniThomas KündigFederica SallustoGünther F.L. HofbauerStefan HaakBurkhard BecherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paulina Kulig Stephanie Musiol Sandra Nicole Freiberger Bettina Schreiner Gabor Gyülveszi Giancarlo Russo Stanislav Pantelyushin Kenji Kishihara Francesca Alessandrini Thomas Kündig Federica Sallusto Günther F.L. Hofbauer Stefan Haak Burkhard Becher IL-12 protects from psoriasiform skin inflammation
description	IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin.
format	article
author	Paulina Kulig Stephanie Musiol Sandra Nicole Freiberger Bettina Schreiner Gabor Gyülveszi Giancarlo Russo Stanislav Pantelyushin Kenji Kishihara Francesca Alessandrini Thomas Kündig Federica Sallusto Günther F.L. Hofbauer Stefan Haak Burkhard Becher
author_facet	Paulina Kulig Stephanie Musiol Sandra Nicole Freiberger Bettina Schreiner Gabor Gyülveszi Giancarlo Russo Stanislav Pantelyushin Kenji Kishihara Francesca Alessandrini Thomas Kündig Federica Sallusto Günther F.L. Hofbauer Stefan Haak Burkhard Becher
author_sort	Paulina Kulig
title	IL-12 protects from psoriasiform skin inflammation
title_short	IL-12 protects from psoriasiform skin inflammation
title_full	IL-12 protects from psoriasiform skin inflammation
title_fullStr	IL-12 protects from psoriasiform skin inflammation
title_full_unstemmed	IL-12 protects from psoriasiform skin inflammation
title_sort	il-12 protects from psoriasiform skin inflammation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/65cfea74d59d466a9e896738ae39f149
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IL-12 protects from psoriasiform skin inflammation

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