CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions

CRISPR/Cas is a powerful tool for studying the role of genes in viral infections. The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identi...

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Auteurs principaux:	Vladimir Chulanov, Anastasiya Kostyusheva, Sergey Brezgin, Natalia Ponomareva, Vladimir Gegechkori, Elena Volchkova, Nikolay Pimenov, Dmitry Kostyushev
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	SARS-CoV-2 COVID-19 hepatitis HIV Cas12 Cas9 Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/65d01ee8aa7b43caa0a215a8184969a2
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spelling	oai:doaj.org-article:65d01ee8aa7b43caa0a215a8184969a22021-11-25T19:13:51ZCRISPR Screening: Molecular Tools for Studying Virus–Host Interactions10.3390/v131122581999-4915https://doaj.org/article/65d01ee8aa7b43caa0a215a8184969a22021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2258https://doaj.org/toc/1999-4915CRISPR/Cas is a powerful tool for studying the role of genes in viral infections. The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identification of novel drug candidates for treating viral infections. In this review, we highlight recent developments in the fields of CRISPR/Cas with a focus on the use of CRISPR screens for studying viral infections and identifying new candidate genes to aid development of antivirals.Vladimir ChulanovAnastasiya KostyushevaSergey BrezginNatalia PonomarevaVladimir GegechkoriElena VolchkovaNikolay PimenovDmitry KostyushevMDPI AGarticleSARS-CoV-2COVID-19hepatitisHIVCas12Cas9MicrobiologyQR1-502ENViruses, Vol 13, Iss 2258, p 2258 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 hepatitis HIV Cas12 Cas9 Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 hepatitis HIV Cas12 Cas9 Microbiology QR1-502 Vladimir Chulanov Anastasiya Kostyusheva Sergey Brezgin Natalia Ponomareva Vladimir Gegechkori Elena Volchkova Nikolay Pimenov Dmitry Kostyushev CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
description	CRISPR/Cas is a powerful tool for studying the role of genes in viral infections. The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identification of novel drug candidates for treating viral infections. In this review, we highlight recent developments in the fields of CRISPR/Cas with a focus on the use of CRISPR screens for studying viral infections and identifying new candidate genes to aid development of antivirals.
format	article
author	Vladimir Chulanov Anastasiya Kostyusheva Sergey Brezgin Natalia Ponomareva Vladimir Gegechkori Elena Volchkova Nikolay Pimenov Dmitry Kostyushev
author_facet	Vladimir Chulanov Anastasiya Kostyusheva Sergey Brezgin Natalia Ponomareva Vladimir Gegechkori Elena Volchkova Nikolay Pimenov Dmitry Kostyushev
author_sort	Vladimir Chulanov
title	CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
title_short	CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
title_full	CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
title_fullStr	CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
title_full_unstemmed	CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
title_sort	crispr screening: molecular tools for studying virus–host interactions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/65d01ee8aa7b43caa0a215a8184969a2
work_keys_str_mv	AT vladimirchulanov crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT anastasiyakostyusheva crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT sergeybrezgin crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT nataliaponomareva crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT vladimirgegechkori crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT elenavolchkova crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT nikolaypimenov crisprscreeningmoleculartoolsforstudyingvirushostinteractions AT dmitrykostyushev crisprscreeningmoleculartoolsforstudyingvirushostinteractions
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CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions

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