Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention

Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects. A wide range of plant-derived compounds have been reported...

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Autores principales:	Pratibha Pandey, Fahad Khan, Huda A. Qari, Mohammad Oves
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	rutin therapeutic potential cancer cell signaling pathways miRNA Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/65d026f203e2442cb2606c86de568b4a
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spelling	oai:doaj.org-article:65d026f203e2442cb2606c86de568b4a2021-11-25T18:39:05ZRutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention10.3390/ph141110691424-8247https://doaj.org/article/65d026f203e2442cb2606c86de568b4a2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1069https://doaj.org/toc/1424-8247Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects. A wide range of plant-derived compounds have been reported for their anticancer potential in the quest of finding an effective therapeutic approach. Rutin (vitamin P) is a low-molecular weight flavonoid glycoside (polyphenolic compound), abundantly present in various vegetables, fruits (especially berries and citrus fruits), and medicinal herbs. Numerous studies have delineated several pharmacological properties of rutin such as its antiprotozoal, antibacterial, anti-inflammatory, antitumor, antiviral, antiallergic, vasoactive, cytoprotective, antispasmodic, hypolipidemic, antihypertensive, and antiplatelet properties. Specifically, rutin-mediated anticancerous activities have been reported in several cancerous cell lines, but the most common scientific evidence, encompassing several molecular processes and interactions, including apoptosis pathway regulation, aberrant cell signaling pathways, and oncogenic genes, has not been thoroughly studied. In this direction, we attempted to project rutin-mediated oncogenic pathway regulation in various carcinomas. Additionally, we also incorporated advanced research that has uncovered the notable potential of rutin in the modulation of several key cellular functions via interaction with mRNAs, with major emphasis on elucidating direct miRNA targets of rutin as well as the process needed to transform these approaches for developing novel therapeutic interventions for the treatment of several cancers.Pratibha PandeyFahad KhanHuda A. QariMohammad OvesMDPI AGarticlerutintherapeutic potentialcancercell signaling pathwaysmiRNAMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1069, p 1069 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rutin therapeutic potential cancer cell signaling pathways miRNA Medicine R Pharmacy and materia medica RS1-441
spellingShingle	rutin therapeutic potential cancer cell signaling pathways miRNA Medicine R Pharmacy and materia medica RS1-441 Pratibha Pandey Fahad Khan Huda A. Qari Mohammad Oves Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
description	Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects. A wide range of plant-derived compounds have been reported for their anticancer potential in the quest of finding an effective therapeutic approach. Rutin (vitamin P) is a low-molecular weight flavonoid glycoside (polyphenolic compound), abundantly present in various vegetables, fruits (especially berries and citrus fruits), and medicinal herbs. Numerous studies have delineated several pharmacological properties of rutin such as its antiprotozoal, antibacterial, anti-inflammatory, antitumor, antiviral, antiallergic, vasoactive, cytoprotective, antispasmodic, hypolipidemic, antihypertensive, and antiplatelet properties. Specifically, rutin-mediated anticancerous activities have been reported in several cancerous cell lines, but the most common scientific evidence, encompassing several molecular processes and interactions, including apoptosis pathway regulation, aberrant cell signaling pathways, and oncogenic genes, has not been thoroughly studied. In this direction, we attempted to project rutin-mediated oncogenic pathway regulation in various carcinomas. Additionally, we also incorporated advanced research that has uncovered the notable potential of rutin in the modulation of several key cellular functions via interaction with mRNAs, with major emphasis on elucidating direct miRNA targets of rutin as well as the process needed to transform these approaches for developing novel therapeutic interventions for the treatment of several cancers.
format	article
author	Pratibha Pandey Fahad Khan Huda A. Qari Mohammad Oves
author_facet	Pratibha Pandey Fahad Khan Huda A. Qari Mohammad Oves
author_sort	Pratibha Pandey
title	Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
title_short	Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
title_full	Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
title_fullStr	Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
title_full_unstemmed	Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention
title_sort	rutin (bioflavonoid) as cell signaling pathway modulator: prospects in treatment and chemoprevention
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/65d026f203e2442cb2606c86de568b4a
work_keys_str_mv	AT pratibhapandey rutinbioflavonoidascellsignalingpathwaymodulatorprospectsintreatmentandchemoprevention AT fahadkhan rutinbioflavonoidascellsignalingpathwaymodulatorprospectsintreatmentandchemoprevention AT hudaaqari rutinbioflavonoidascellsignalingpathwaymodulatorprospectsintreatmentandchemoprevention AT mohammadoves rutinbioflavonoidascellsignalingpathwaymodulatorprospectsintreatmentandchemoprevention
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Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention

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