Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)

Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)

A severe pandemic of CoronaVirus disease 2019 (COVID-19), according to World Health Organization (WHO), appeared in China in December 2019, and spread rapidly. The majority of the patients had mild symptoms and good prognosis after recovery; however some patients developed severe inflammatory reacti...

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Autor principal: Nikolaos Chrysanthakopoulos
Formato: article
Lenguaje:EN
Publicado: Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:
infection
coronavirus
covid-19
immune system
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/65d2780c37804249afe8cff21a14f544
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spelling oai:doaj.org-article:65d2780c37804249afe8cff21a14f5442021-12-02T19:15:00ZHistopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)10.5281/zenodo.38238592695-5075https://doaj.org/article/65d2780c37804249afe8cff21a14f5442020-05-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3823859https://doaj.org/toc/2695-5075A severe pandemic of CoronaVirus disease 2019 (COVID-19), according to World Health Organization (WHO), appeared in China in December 2019, and spread rapidly. The majority of the patients had mild symptoms and good prognosis after recovery; however some patients developed severe inflammatory reaction and passed away from multiple organ complications. The novel coronavirus, Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a beta-coronavirus and is similar with the Severe Acute Respiratory Syndrome Corona Virus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). SARS-CoV-2 and -1 have the same host receptor, the angiotensin-converting enzyme 2 (ACE2). The pathogenesis of SARS-CoV-2 infection in humans remains unclear. The immune response is essential to control and reduce SARS-CoV-1 and -2 infections, however, irregular and exaggerated immune responses may lead to the immunopathology of the disease and the lung lesions. This article presents the immunological features of SARS-CoV-2 infection and its potential pathogenesis based on the recent observations of the International literature.Nikolaos ChrysanthakopoulosEmergency Department of Hospital San Pedro (Logroño, Spain)articleinfectioncoronaviruscovid-19immune systemMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 3, Pp 230-234 (2020)
institution DOAJ
collection DOAJ
language EN
topic infection
coronavirus
covid-19
immune system
Medicine (General)
R5-920
spellingShingle infection
coronavirus
covid-19
immune system
Medicine (General)
R5-920
Nikolaos Chrysanthakopoulos
Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
description A severe pandemic of CoronaVirus disease 2019 (COVID-19), according to World Health Organization (WHO), appeared in China in December 2019, and spread rapidly. The majority of the patients had mild symptoms and good prognosis after recovery; however some patients developed severe inflammatory reaction and passed away from multiple organ complications. The novel coronavirus, Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a beta-coronavirus and is similar with the Severe Acute Respiratory Syndrome Corona Virus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). SARS-CoV-2 and -1 have the same host receptor, the angiotensin-converting enzyme 2 (ACE2). The pathogenesis of SARS-CoV-2 infection in humans remains unclear. The immune response is essential to control and reduce SARS-CoV-1 and -2 infections, however, irregular and exaggerated immune responses may lead to the immunopathology of the disease and the lung lesions. This article presents the immunological features of SARS-CoV-2 infection and its potential pathogenesis based on the recent observations of the International literature.
format article
author Nikolaos Chrysanthakopoulos
author_facet Nikolaos Chrysanthakopoulos
author_sort Nikolaos Chrysanthakopoulos
title Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
title_short Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
title_full Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
title_fullStr Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
title_full_unstemmed Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)
title_sort histopathology and pathogenesis of coronavirus disease 2019 (covid-19)
publisher Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate 2020
url https://doaj.org/article/65d2780c37804249afe8cff21a14f544
work_keys_str_mv AT nikolaoschrysanthakopoulos histopathologyandpathogenesisofcoronavirusdisease2019covid19
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