Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their...

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Autores principales: A. Laustsen, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, P. W. Denton, M. R. Jakobsen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c0
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spelling oai:doaj.org-article:65d3ab2f2bc74e388e4cc02a89ab68c02021-12-02T17:32:30ZInterferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function10.1038/s41467-018-05816-y2041-1723https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c02018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05816-yhttps://doaj.org/toc/2041-1723Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.A. LaustsenR. O. BakC. KrappL. KjærJ. H. EgedahlC. C. PetersenS. PillaiH. Q. TangN. UldbjergM. PorteusN. R. RoanM. NyegaardP. W. DentonM. R. JakobsenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. Laustsen
R. O. Bak
C. Krapp
L. Kjær
J. H. Egedahl
C. C. Petersen
S. Pillai
H. Q. Tang
N. Uldbjerg
M. Porteus
N. R. Roan
M. Nyegaard
P. W. Denton
M. R. Jakobsen
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
description Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.
format article
author A. Laustsen
R. O. Bak
C. Krapp
L. Kjær
J. H. Egedahl
C. C. Petersen
S. Pillai
H. Q. Tang
N. Uldbjerg
M. Porteus
N. R. Roan
M. Nyegaard
P. W. Denton
M. R. Jakobsen
author_facet A. Laustsen
R. O. Bak
C. Krapp
L. Kjær
J. H. Egedahl
C. C. Petersen
S. Pillai
H. Q. Tang
N. Uldbjerg
M. Porteus
N. R. Roan
M. Nyegaard
P. W. Denton
M. R. Jakobsen
author_sort A. Laustsen
title Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_short Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_full Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_fullStr Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_full_unstemmed Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_sort interferon priming is essential for human cd34+ cell-derived plasmacytoid dendritic cell maturation and function
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c0
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