Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their...

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Auteurs principaux:	A. Laustsen, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, P. W. Denton, M. R. Jakobsen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c0
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spelling	oai:doaj.org-article:65d3ab2f2bc74e388e4cc02a89ab68c02021-12-02T17:32:30ZInterferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function10.1038/s41467-018-05816-y2041-1723https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c02018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05816-yhttps://doaj.org/toc/2041-1723Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.A. LaustsenR. O. BakC. KrappL. KjærJ. H. EgedahlC. C. PetersenS. PillaiH. Q. TangN. UldbjergM. PorteusN. R. RoanM. NyegaardP. W. DentonM. R. JakobsenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Laustsen R. O. Bak C. Krapp L. Kjær J. H. Egedahl C. C. Petersen S. Pillai H. Q. Tang N. Uldbjerg M. Porteus N. R. Roan M. Nyegaard P. W. Denton M. R. Jakobsen Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
description	Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.
format	article
author	A. Laustsen R. O. Bak C. Krapp L. Kjær J. H. Egedahl C. C. Petersen S. Pillai H. Q. Tang N. Uldbjerg M. Porteus N. R. Roan M. Nyegaard P. W. Denton M. R. Jakobsen
author_facet	A. Laustsen R. O. Bak C. Krapp L. Kjær J. H. Egedahl C. C. Petersen S. Pillai H. Q. Tang N. Uldbjerg M. Porteus N. R. Roan M. Nyegaard P. W. Denton M. R. Jakobsen
author_sort	A. Laustsen
title	Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_short	Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_full	Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_fullStr	Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_full_unstemmed	Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
title_sort	interferon priming is essential for human cd34+ cell-derived plasmacytoid dendritic cell maturation and function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/65d3ab2f2bc74e388e4cc02a89ab68c0
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Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

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