SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY

The purpose of the present study was to specify a role of inflammatory mediators in pathogenesis of various types of anemia in pregnant obese women. We determined IL-1, IL-6, TNFα, C-reactive protein and hepcidin concentrations in blood serum of pregnant women with obesity depending on the type of a...

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Autores principales:	Т. S. Prokhorenko, A. P. Zima, T. V. Saprina, N. N. Musina, N. S. Shakhmanova, O. A. Vasilyeva, V. V. Novitsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	anemia of chronic diseases pregnancy obesity gestational diabetes mellitus cytokines hepcidin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/65d457d246ab45c79ed0468519a8b507
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spelling	oai:doaj.org-article:65d457d246ab45c79ed0468519a8b5072021-11-18T08:03:47ZSIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY1563-06252313-741X10.15789/1563-0625-2018-5-639-646https://doaj.org/article/65d457d246ab45c79ed0468519a8b5072018-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1632https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe purpose of the present study was to specify a role of inflammatory mediators in pathogenesis of various types of anemia in pregnant obese women. We determined IL-1, IL-6, TNFα, C-reactive protein and hepcidin concentrations in blood serum of pregnant women with obesity depending on the type of anemic syndrome, either iron-deficiency anemia, or anemia of chronic diseases. We showed that the content of IL-6 in blood of the obese women exceeds the value of this index in healthy pregnant women (p < 0.05), and it does not depend on the presence and type of anemic syndrome. We found that the C-reactive protein concentration in pregnant women with obesity is higher than reference values (p < 0.05). Moreover, the contents of C-reactive protein in blood serum of pregnant women with anemia of chronic diseases is significantly higher (p < 0.05) than in women with iron deficiency anemia. Hepcidin concentration in blood of pregnant women with obesity and anemia of chronic disease was a specific feature: its content was significantly higher than in healthy pregnant women (p < 0.05), or in pregnant women with anemia-free obesity (p < 0.05). Hepcidin levels also exceeded 2-fold its contents in serum from pregnant women with obesity and iron deficiency anemia (p < 0.05). We have found that only pregnant women with obesity and anemia of chronic diseases have shown a positive correlation between the concentrations of C-reactive protein and blood levels of hepcidin (r = 0.733, p < 0.05), or IL-6 (r = 0.679, p < 0.05).The discussion concerns potential mechanisms of evolving anemia of chronic disease combined with subclinical inflammation in pregnant women with metabolic disorders. We conclude that a combination of obesity with gestational diabetes is a risk factor of anemia of chronic diseases in pregnant women. Development of an algorithm for differential diagnosis of iron deficiency anemia and anemia of chronic diseases in this cohort of patients is advisable for future studies in the area.Т. S. ProkhorenkoA. P. ZimaT. V. SaprinaN. N. MusinaN. S. ShakhmanovaO. A. VasilyevaV. V. NovitskySPb RAACIarticleanemia of chronic diseasespregnancyobesitygestational diabetes mellituscytokineshepcidinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 5, Pp 639-646 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	anemia of chronic diseases pregnancy obesity gestational diabetes mellitus cytokines hepcidin Immunologic diseases. Allergy RC581-607
spellingShingle	anemia of chronic diseases pregnancy obesity gestational diabetes mellitus cytokines hepcidin Immunologic diseases. Allergy RC581-607 Т. S. Prokhorenko A. P. Zima T. V. Saprina N. N. Musina N. S. Shakhmanova O. A. Vasilyeva V. V. Novitsky SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
description	The purpose of the present study was to specify a role of inflammatory mediators in pathogenesis of various types of anemia in pregnant obese women. We determined IL-1, IL-6, TNFα, C-reactive protein and hepcidin concentrations in blood serum of pregnant women with obesity depending on the type of anemic syndrome, either iron-deficiency anemia, or anemia of chronic diseases. We showed that the content of IL-6 in blood of the obese women exceeds the value of this index in healthy pregnant women (p < 0.05), and it does not depend on the presence and type of anemic syndrome. We found that the C-reactive protein concentration in pregnant women with obesity is higher than reference values (p < 0.05). Moreover, the contents of C-reactive protein in blood serum of pregnant women with anemia of chronic diseases is significantly higher (p < 0.05) than in women with iron deficiency anemia. Hepcidin concentration in blood of pregnant women with obesity and anemia of chronic disease was a specific feature: its content was significantly higher than in healthy pregnant women (p < 0.05), or in pregnant women with anemia-free obesity (p < 0.05). Hepcidin levels also exceeded 2-fold its contents in serum from pregnant women with obesity and iron deficiency anemia (p < 0.05). We have found that only pregnant women with obesity and anemia of chronic diseases have shown a positive correlation between the concentrations of C-reactive protein and blood levels of hepcidin (r = 0.733, p < 0.05), or IL-6 (r = 0.679, p < 0.05).The discussion concerns potential mechanisms of evolving anemia of chronic disease combined with subclinical inflammation in pregnant women with metabolic disorders. We conclude that a combination of obesity with gestational diabetes is a risk factor of anemia of chronic diseases in pregnant women. Development of an algorithm for differential diagnosis of iron deficiency anemia and anemia of chronic diseases in this cohort of patients is advisable for future studies in the area.
format	article
author	Т. S. Prokhorenko A. P. Zima T. V. Saprina N. N. Musina N. S. Shakhmanova O. A. Vasilyeva V. V. Novitsky
author_facet	Т. S. Prokhorenko A. P. Zima T. V. Saprina N. N. Musina N. S. Shakhmanova O. A. Vasilyeva V. V. Novitsky
author_sort	Т. S. Prokhorenko
title	SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
title_short	SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
title_full	SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
title_fullStr	SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
title_full_unstemmed	SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY
title_sort	significance of inflammation markers determined in pregnant women with anemic syndrome and obesity
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/65d457d246ab45c79ed0468519a8b507
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SIGNIFICANCE OF INFLAMMATION MARKERS DETERMINED IN PREGNANT WOMEN WITH ANEMIC SYNDROME AND OBESITY

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