Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology

Long non-coding RNAs (lncRNAs) are involved in fundamental biochemical and cellular processes. The neighbor of BRCA1 gene 2 (NBR2) is a long intergenic non-coding RNA (lincRNA) whose gene locus is adjacent to the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1). In human cancers, NB...

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Autores principales:	Ting Wang, Zhaosheng Li, Liujia Yan, Feng Yan, Han Shen, Xinyu Tian
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	long non-coding RNA neighbor of BRCA1 gene 2 cancer metabolism epithelial-mesenchymal transition autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/65decae1395c44949242cc790778a15f
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id	oai:doaj.org-article:65decae1395c44949242cc790778a15f
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spelling	oai:doaj.org-article:65decae1395c44949242cc790778a15f2021-12-02T10:05:58ZLong Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology2234-943X10.3389/fonc.2021.783526https://doaj.org/article/65decae1395c44949242cc790778a15f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.783526/fullhttps://doaj.org/toc/2234-943XLong non-coding RNAs (lncRNAs) are involved in fundamental biochemical and cellular processes. The neighbor of BRCA1 gene 2 (NBR2) is a long intergenic non-coding RNA (lincRNA) whose gene locus is adjacent to the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1). In human cancers, NBR2 expression is dysregulated and correlates with clinical outcomes. Moreover, NBR2 is crucial for glucose metabolism and affects the proliferation, survival, metastasis, and therapeutic resistance in different types of cancer. Here, we review the precise molecular mechanisms underlying NBR2-induced changes in cancer. In addition, the potential application of NBR2 in the diagnosis and treatment of cancer is also discussed, as well as the challenges of exploiting NBR2 for cancer intervention.Ting WangZhaosheng LiLiujia YanFeng YanHan ShenXinyu TianFrontiers Media S.A.articlelong non-coding RNAneighbor of BRCA1 gene 2cancermetabolismepithelial-mesenchymal transitionautophagyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA neighbor of BRCA1 gene 2 cancer metabolism epithelial-mesenchymal transition autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	long non-coding RNA neighbor of BRCA1 gene 2 cancer metabolism epithelial-mesenchymal transition autophagy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ting Wang Zhaosheng Li Liujia Yan Feng Yan Han Shen Xinyu Tian Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
description	Long non-coding RNAs (lncRNAs) are involved in fundamental biochemical and cellular processes. The neighbor of BRCA1 gene 2 (NBR2) is a long intergenic non-coding RNA (lincRNA) whose gene locus is adjacent to the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1). In human cancers, NBR2 expression is dysregulated and correlates with clinical outcomes. Moreover, NBR2 is crucial for glucose metabolism and affects the proliferation, survival, metastasis, and therapeutic resistance in different types of cancer. Here, we review the precise molecular mechanisms underlying NBR2-induced changes in cancer. In addition, the potential application of NBR2 in the diagnosis and treatment of cancer is also discussed, as well as the challenges of exploiting NBR2 for cancer intervention.
format	article
author	Ting Wang Zhaosheng Li Liujia Yan Feng Yan Han Shen Xinyu Tian
author_facet	Ting Wang Zhaosheng Li Liujia Yan Feng Yan Han Shen Xinyu Tian
author_sort	Ting Wang
title	Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
title_short	Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
title_full	Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
title_fullStr	Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
title_full_unstemmed	Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
title_sort	long non-coding rna neighbor of brca1 gene 2: a crucial regulator in cancer biology
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/65decae1395c44949242cc790778a15f
work_keys_str_mv	AT tingwang longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology AT zhaoshengli longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology AT liujiayan longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology AT fengyan longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology AT hanshen longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology AT xinyutian longnoncodingrnaneighborofbrca1gene2acrucialregulatorincancerbiology
_version_	1718397641471033344

Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology

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