Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease

Abstract The gut-microbiota–brain axis plays an important role in stress-related disorders, and dysfunction of this complex bidirectional system is associated with Alzheimer’s disease. This study aimed to assess the idea that whether gut microbiota depletion from early adolescence can alter anxiety-...

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Autores principales:	Belal Mosaferi, Yahya Jand, Ali-Akbar Salari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65e582a1b14d4a909ce87af7ea98382d
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spelling	oai:doaj.org-article:65e582a1b14d4a909ce87af7ea98382d2021-11-28T12:21:20ZGut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease10.1038/s41598-021-02231-02045-2322https://doaj.org/article/65e582a1b14d4a909ce87af7ea98382d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02231-0https://doaj.org/toc/2045-2322Abstract The gut-microbiota–brain axis plays an important role in stress-related disorders, and dysfunction of this complex bidirectional system is associated with Alzheimer’s disease. This study aimed to assess the idea that whether gut microbiota depletion from early adolescence can alter anxiety- and depression-related behaviours in adult mice with or without Alzheimer-like disease. Male C57BL/6 mice were treated with an antibiotic cocktail from weaning to adulthood. Adult mice received an intracerebroventricular injection of amyloid-beta (Aβ)1–42, and were subjected to anxiety and depression tests. We measured, brain malondialdehyde and glutathione following anxiety tests, and assessed brain oxytocin and the hypothalamic–pituitary–adrenal (HPA) axis function by measuring adrenocorticotrophic hormone (ACTH) and corticosterone following depression tests. Healthy antibiotic-treated mice displayed significant decreases in anxiety-like behaviours, whereas they did not show any alterations in depression-like behaviours and HPA axis function. Antibiotic treatment from early adolescence prevented the development of anxiety- and depression-related behaviours, oxidative stress and HPA axis dysregulation in Alzheimer-induced mice. Antibiotic treatment increased oxytocin in the brain of healthy but not Alzheimer-induced mice. Taken together, these findings suggest that gut microbiota depletion following antibiotic treatment from early adolescence might profoundly affect anxiety- and depression-related behaviours, and HPA axis function in adult mice with Alzheimer-like disease.Belal MosaferiYahya JandAli-Akbar SalariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Belal Mosaferi Yahya Jand Ali-Akbar Salari Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
description	Abstract The gut-microbiota–brain axis plays an important role in stress-related disorders, and dysfunction of this complex bidirectional system is associated with Alzheimer’s disease. This study aimed to assess the idea that whether gut microbiota depletion from early adolescence can alter anxiety- and depression-related behaviours in adult mice with or without Alzheimer-like disease. Male C57BL/6 mice were treated with an antibiotic cocktail from weaning to adulthood. Adult mice received an intracerebroventricular injection of amyloid-beta (Aβ)1–42, and were subjected to anxiety and depression tests. We measured, brain malondialdehyde and glutathione following anxiety tests, and assessed brain oxytocin and the hypothalamic–pituitary–adrenal (HPA) axis function by measuring adrenocorticotrophic hormone (ACTH) and corticosterone following depression tests. Healthy antibiotic-treated mice displayed significant decreases in anxiety-like behaviours, whereas they did not show any alterations in depression-like behaviours and HPA axis function. Antibiotic treatment from early adolescence prevented the development of anxiety- and depression-related behaviours, oxidative stress and HPA axis dysregulation in Alzheimer-induced mice. Antibiotic treatment increased oxytocin in the brain of healthy but not Alzheimer-induced mice. Taken together, these findings suggest that gut microbiota depletion following antibiotic treatment from early adolescence might profoundly affect anxiety- and depression-related behaviours, and HPA axis function in adult mice with Alzheimer-like disease.
format	article
author	Belal Mosaferi Yahya Jand Ali-Akbar Salari
author_facet	Belal Mosaferi Yahya Jand Ali-Akbar Salari
author_sort	Belal Mosaferi
title	Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
title_short	Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
title_full	Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
title_fullStr	Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
title_full_unstemmed	Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease
title_sort	gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with alzheimer-like disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65e582a1b14d4a909ce87af7ea98382d
work_keys_str_mv	AT belalmosaferi gutmicrobiotadepletionfromearlyadolescencealtersanxietyanddepressionrelatedbehavioursinmalemicewithalzheimerlikedisease AT yahyajand gutmicrobiotadepletionfromearlyadolescencealtersanxietyanddepressionrelatedbehavioursinmalemicewithalzheimerlikedisease AT aliakbarsalari gutmicrobiotadepletionfromearlyadolescencealtersanxietyanddepressionrelatedbehavioursinmalemicewithalzheimerlikedisease
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Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease

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