Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort

Abstract The objective was to examine whether: (1) statin use was associated with muscle related outcomes at age 60–64, (2) these associations were modified by 25-hydroxyvitamin D (25(OH)D) status and explained by inflammation, body-size or lifestyle in a British birth cohort. Markers of myalgia (in...

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Autores principales:	Nikhil Sharma, Rachel Cooper, Diana Kuh, Imran Shah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65e668fe3e09456b907d16429db1d06d
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spelling	oai:doaj.org-article:65e668fe3e09456b907d16429db1d06d2021-12-02T16:07:44ZAssociations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort10.1038/s41598-017-06019-z2045-2322https://doaj.org/article/65e668fe3e09456b907d16429db1d06d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06019-zhttps://doaj.org/toc/2045-2322Abstract The objective was to examine whether: (1) statin use was associated with muscle related outcomes at age 60–64, (2) these associations were modified by 25-hydroxyvitamin D (25(OH)D) status and explained by inflammation, body-size or lifestyle in a British birth cohort. Markers of myalgia (intrusive body pain) and myopathy (self-reported and performance-based measures) were examined in 734 men and 822 women (MRC National Survey of Health and Development). Statin use was associated with intrusive body pain, difficulty climbing stairs and slower chair rise speed. Some associations were modified by 25(OH)D e.g. the association with intrusive body pain was evident in the insufficient (13–20 ng/l) and deficient (<13 ng/l) 25(OH)D status groups (OR = 2.6,95% CI 1.7–1.1; OR = 1.8,95% CI 1.2–2.8, respectively) but not in those with status >20 ng/l (OR = 0.8,95% CI 0.5–1.4) (p = 0.003 for interaction). Associations were maintained in fully adjusted models of intrusive body pain and difficulty climbing stairs, but for chair rise speed they were fully accounted for by inflammation, body-size and lifestyle. In a nationally representative British population in early old age, statin use was associated with lower limb muscle-related outcomes, and some were only apparent in those with 25(OH)D status below 20 ng/l. Given 25(OH)D is modifiable in clinical practice, future studies should consider the links between 25(OH)D status and muscle related outcomes.Nikhil SharmaRachel CooperDiana KuhImran ShahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nikhil Sharma Rachel Cooper Diana Kuh Imran Shah Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
description	Abstract The objective was to examine whether: (1) statin use was associated with muscle related outcomes at age 60–64, (2) these associations were modified by 25-hydroxyvitamin D (25(OH)D) status and explained by inflammation, body-size or lifestyle in a British birth cohort. Markers of myalgia (intrusive body pain) and myopathy (self-reported and performance-based measures) were examined in 734 men and 822 women (MRC National Survey of Health and Development). Statin use was associated with intrusive body pain, difficulty climbing stairs and slower chair rise speed. Some associations were modified by 25(OH)D e.g. the association with intrusive body pain was evident in the insufficient (13–20 ng/l) and deficient (<13 ng/l) 25(OH)D status groups (OR = 2.6,95% CI 1.7–1.1; OR = 1.8,95% CI 1.2–2.8, respectively) but not in those with status >20 ng/l (OR = 0.8,95% CI 0.5–1.4) (p = 0.003 for interaction). Associations were maintained in fully adjusted models of intrusive body pain and difficulty climbing stairs, but for chair rise speed they were fully accounted for by inflammation, body-size and lifestyle. In a nationally representative British population in early old age, statin use was associated with lower limb muscle-related outcomes, and some were only apparent in those with 25(OH)D status below 20 ng/l. Given 25(OH)D is modifiable in clinical practice, future studies should consider the links between 25(OH)D status and muscle related outcomes.
format	article
author	Nikhil Sharma Rachel Cooper Diana Kuh Imran Shah
author_facet	Nikhil Sharma Rachel Cooper Diana Kuh Imran Shah
author_sort	Nikhil Sharma
title	Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
title_short	Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
title_full	Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
title_fullStr	Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
title_full_unstemmed	Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort
title_sort	associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin d: findings from a british birth cohort
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65e668fe3e09456b907d16429db1d06d
work_keys_str_mv	AT nikhilsharma associationsofstatinusewithmotorperformanceandmyalgiamaybemodifiedby25hydroxyvitamindfindingsfromabritishbirthcohort AT rachelcooper associationsofstatinusewithmotorperformanceandmyalgiamaybemodifiedby25hydroxyvitamindfindingsfromabritishbirthcohort AT dianakuh associationsofstatinusewithmotorperformanceandmyalgiamaybemodifiedby25hydroxyvitamindfindingsfromabritishbirthcohort AT imranshah associationsofstatinusewithmotorperformanceandmyalgiamaybemodifiedby25hydroxyvitamindfindingsfromabritishbirthcohort
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Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort

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