MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.

Guardado en:

Detalles Bibliográficos
Autores principales:	Huan-Chang Zeng, Yangjin Bae, Brian C. Dawson, Yuqing Chen, Terry Bertin, Elda Munivez, Philippe M. Campeau, Jianning Tao, Rui Chen, Brendan H. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65e76af7312b408ab752cc27fdd3ab65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:65e76af7312b408ab752cc27fdd3ab65
record_format	dspace
spelling	oai:doaj.org-article:65e76af7312b408ab752cc27fdd3ab652021-12-02T17:06:14ZMicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts10.1038/ncomms150002041-1723https://doaj.org/article/65e76af7312b408ab752cc27fdd3ab652017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15000https://doaj.org/toc/2041-1723Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.Huan-Chang ZengYangjin BaeBrian C. DawsonYuqing ChenTerry BertinElda MunivezPhilippe M. CampeauJianning TaoRui ChenBrendan H. LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan-Chang Zeng Yangjin Bae Brian C. Dawson Yuqing Chen Terry Bertin Elda Munivez Philippe M. Campeau Jianning Tao Rui Chen Brendan H. Lee MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
description	Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.
format	article
author	Huan-Chang Zeng Yangjin Bae Brian C. Dawson Yuqing Chen Terry Bertin Elda Munivez Philippe M. Campeau Jianning Tao Rui Chen Brendan H. Lee
author_facet	Huan-Chang Zeng Yangjin Bae Brian C. Dawson Yuqing Chen Terry Bertin Elda Munivez Philippe M. Campeau Jianning Tao Rui Chen Brendan H. Lee
author_sort	Huan-Chang Zeng
title	MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
title_short	MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
title_full	MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
title_fullStr	MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
title_full_unstemmed	MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
title_sort	microrna mir-23a cluster promotes osteocyte differentiation by regulating tgf-β signalling in osteoblasts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65e76af7312b408ab752cc27fdd3ab65
work_keys_str_mv	AT huanchangzeng micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT yangjinbae micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT briancdawson micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT yuqingchen micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT terrybertin micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT eldamunivez micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT philippemcampeau micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT jianningtao micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT ruichen micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts AT brendanhlee micrornamir23aclusterpromotesosteocytedifferentiationbyregulatingtgfbsignallinginosteoblasts
_version_	1718381677603979264

MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

Ejemplares similares