Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and that accumulation of proteasome substrates activat...

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Auteurs principaux:	Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
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spelling	oai:doaj.org-article:65e9ecff6a5e4bf9bde0b3289d2495182021-12-02T16:49:35ZArtemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome10.1038/s41467-018-06221-12041-1723https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d2495182018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06221-1https://doaj.org/toc/2041-1723Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and that accumulation of proteasome substrates activates the ER stress response.Jessica L. BridgfordStanley C. XieSimon A. CobboldCharisse Flerida A. PasajeSusann HerrmannTuo YangDavid L. GillettLawrence R. DickStuart A. RalphCon DogovskiNatalie J. SpillmanLeann TilleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica L. Bridgford Stanley C. Xie Simon A. Cobbold Charisse Flerida A. Pasaje Susann Herrmann Tuo Yang David L. Gillett Lawrence R. Dick Stuart A. Ralph Con Dogovski Natalie J. Spillman Leann Tilley Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
description	Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and that accumulation of proteasome substrates activates the ER stress response.
format	article
author	Jessica L. Bridgford Stanley C. Xie Simon A. Cobbold Charisse Flerida A. Pasaje Susann Herrmann Tuo Yang David L. Gillett Lawrence R. Dick Stuart A. Ralph Con Dogovski Natalie J. Spillman Leann Tilley
author_facet	Jessica L. Bridgford Stanley C. Xie Simon A. Cobbold Charisse Flerida A. Pasaje Susann Herrmann Tuo Yang David L. Gillett Lawrence R. Dick Stuart A. Ralph Con Dogovski Natalie J. Spillman Leann Tilley
author_sort	Jessica L. Bridgford
title	Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
title_short	Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
title_full	Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
title_fullStr	Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
title_full_unstemmed	Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
title_sort	artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

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