Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction

Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction

Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't inc...

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Auteurs principaux: M. V. Khutornaya, A. V. Ponasenko, Y. V. Bayrakova, A. S. Golovkin
Format: article
Langue:RU
Publié: Scientific Сentre for Family Health and Human Reproduction Problems 2014
Sujets:
interleukin 1
polymorphisms
genes
smoking
myocardial infarction
ischemic heart disease
risk factors
genetic predisposition
Science
Q
Accès en ligne:https://doaj.org/article/65eecde36de44bafb2f5f5562580e3f3
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Résumé:Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01).

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