Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction

Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't inc...

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Main Authors:	M. V. Khutornaya, A. V. Ponasenko, Y. V. Bayrakova, A. S. Golovkin
Format:	article
Language:	RU
Published:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Subjects:	interleukin 1 polymorphisms genes smoking myocardial infarction ischemic heart disease risk factors genetic predisposition Science Q
Online Access:	https://doaj.org/article/65eecde36de44bafb2f5f5562580e3f3
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spelling	oai:doaj.org-article:65eecde36de44bafb2f5f5562580e3f32021-11-23T06:14:31ZRelationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction2541-94202587-9596https://doaj.org/article/65eecde36de44bafb2f5f5562580e3f32014-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1807https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01).M. V. KhutornayaA. V. PonasenkoY. V. BayrakovaA. S. GolovkinScientific Сentre for Family Health and Human Reproduction Problemsarticleinterleukin 1polymorphismsgenessmokingmyocardial infarctionischemic heart diseaserisk factorsgenetic predispositionScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 30-33 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	interleukin 1 polymorphisms genes smoking myocardial infarction ischemic heart disease risk factors genetic predisposition Science Q
spellingShingle	interleukin 1 polymorphisms genes smoking myocardial infarction ischemic heart disease risk factors genetic predisposition Science Q M. V. Khutornaya A. V. Ponasenko Y. V. Bayrakova A. S. Golovkin Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
description	Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01).
format	article
author	M. V. Khutornaya A. V. Ponasenko Y. V. Bayrakova A. S. Golovkin
author_facet	M. V. Khutornaya A. V. Ponasenko Y. V. Bayrakova A. S. Golovkin
author_sort	M. V. Khutornaya
title	Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
title_short	Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
title_full	Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
title_fullStr	Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
title_full_unstemmed	Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction
title_sort	relationship between il1b gene polymorphism and smoking with the risk of myocardial infarction
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/65eecde36de44bafb2f5f5562580e3f3
work_keys_str_mv	AT mvkhutornaya relationshipbetweenil1bgenepolymorphismandsmokingwiththeriskofmyocardialinfarction AT avponasenko relationshipbetweenil1bgenepolymorphismandsmokingwiththeriskofmyocardialinfarction AT yvbayrakova relationshipbetweenil1bgenepolymorphismandsmokingwiththeriskofmyocardialinfarction AT asgolovkin relationshipbetweenil1bgenepolymorphismandsmokingwiththeriskofmyocardialinfarction
_version_	1718417073221140480

Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction

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