Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.

<h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based c...

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Autores principales:	Cornelia G de Waal, Nynke Weisglas-Kuperus, Johannes B van Goudoever, Frans J Walther, NeoNed Study Group, LNF Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65eede30ebdf463facc74fd6a10e611b
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spelling	oai:doaj.org-article:65eede30ebdf463facc74fd6a10e611b2021-11-18T07:11:23ZMortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.1932-620310.1371/journal.pone.0041302https://doaj.org/article/65eede30ebdf463facc74fd6a10e611b2012-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0041302https://doaj.org/toc/1932-6203<h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based cohort study of all infants born at 23 to 27 weeks of gestation in The Netherlands in 2007. 276 of 345 (80%) infants were born alive. Early neonatal death occurred in 96 (34.8%) live born infants, including 61 cases of delivery room death. 29 (10.5%) infants died during the late neonatal period. Survival rates for live born infants at 23, 24, 25 and 26 weeks of gestation were 0%, 6.7%, 57.9% and 71% respectively. 43.1% of 144 surviving infants developed severe neonatal morbidity (retinopathy of prematurity grade ≥3, bronchopulmonary dysplasia and/or severe brain injury). At two years of age 70.6% of the children had no disability, 17.6% was mild disabled and 11.8% had a moderate-to-severe disability. Severe brain injury (p = 0.028), retinopathy of prematurity grade ≥3 (p = 0.024), low gestational age (p = 0.019) and non-Dutch nationality of the mother (p = 0.004) increased the risk of disability.<h4>Conclusions/significance</h4>52% of extremely preterm infants born in The Netherlands in 2007 survived. Surviving infants had less severe neonatal morbidity compared to previous studies. At two years of age less than 30% of the infants were disabled. Disability was associated with gestational age and neonatal morbidity.Cornelia G de WaalNynke Weisglas-KuperusJohannes B van GoudoeverFrans J WaltherNeoNed Study GroupLNF Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41302 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
description	<h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based cohort study of all infants born at 23 to 27 weeks of gestation in The Netherlands in 2007. 276 of 345 (80%) infants were born alive. Early neonatal death occurred in 96 (34.8%) live born infants, including 61 cases of delivery room death. 29 (10.5%) infants died during the late neonatal period. Survival rates for live born infants at 23, 24, 25 and 26 weeks of gestation were 0%, 6.7%, 57.9% and 71% respectively. 43.1% of 144 surviving infants developed severe neonatal morbidity (retinopathy of prematurity grade ≥3, bronchopulmonary dysplasia and/or severe brain injury). At two years of age 70.6% of the children had no disability, 17.6% was mild disabled and 11.8% had a moderate-to-severe disability. Severe brain injury (p = 0.028), retinopathy of prematurity grade ≥3 (p = 0.024), low gestational age (p = 0.019) and non-Dutch nationality of the mother (p = 0.004) increased the risk of disability.<h4>Conclusions/significance</h4>52% of extremely preterm infants born in The Netherlands in 2007 survived. Surviving infants had less severe neonatal morbidity compared to previous studies. At two years of age less than 30% of the infants were disabled. Disability was associated with gestational age and neonatal morbidity.
format	article
author	Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group
author_facet	Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group
author_sort	Cornelia G de Waal
title	Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
title_short	Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
title_full	Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
title_fullStr	Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
title_full_unstemmed	Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
title_sort	mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in the netherlands in 2007.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/65eede30ebdf463facc74fd6a10e611b
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Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.

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