Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

Resistance to endocrine treatment in ER+/HER2- breast cancer patients remains a significant clinical problem. Here, the authors demonstrate that loss of the MutL mismatch repair complex can serve as a first-in-class predictive biomarker for combinatorial inhibition of HER2 to overcome the emergence...

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Autores principales:	Nindo B. Punturi, Sinem Seker, Vaishnavi Devarakonda, Aloran Mazumder, Rashi Kalra, Ching Hui Chen, Shunqiang Li, Tina Primeau, Matthew J. Ellis, Shyam M. Kavuri, Svasti Haricharan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65ef3b7f9a184674b715885b4857dafc
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spelling	oai:doaj.org-article:65ef3b7f9a184674b715885b4857dafc2021-12-02T15:52:52ZMismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer10.1038/s41467-021-23271-02041-1723https://doaj.org/article/65ef3b7f9a184674b715885b4857dafc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23271-0https://doaj.org/toc/2041-1723Resistance to endocrine treatment in ER+/HER2- breast cancer patients remains a significant clinical problem. Here, the authors demonstrate that loss of the MutL mismatch repair complex can serve as a first-in-class predictive biomarker for combinatorial inhibition of HER2 to overcome the emergence of endocrine treatment resistance.Nindo B. PunturiSinem SekerVaishnavi DevarakondaAloran MazumderRashi KalraChing Hui ChenShunqiang LiTina PrimeauMatthew J. EllisShyam M. KavuriSvasti HaricharanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nindo B. Punturi Sinem Seker Vaishnavi Devarakonda Aloran Mazumder Rashi Kalra Ching Hui Chen Shunqiang Li Tina Primeau Matthew J. Ellis Shyam M. Kavuri Svasti Haricharan Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
description	Resistance to endocrine treatment in ER+/HER2- breast cancer patients remains a significant clinical problem. Here, the authors demonstrate that loss of the MutL mismatch repair complex can serve as a first-in-class predictive biomarker for combinatorial inhibition of HER2 to overcome the emergence of endocrine treatment resistance.
format	article
author	Nindo B. Punturi Sinem Seker Vaishnavi Devarakonda Aloran Mazumder Rashi Kalra Ching Hui Chen Shunqiang Li Tina Primeau Matthew J. Ellis Shyam M. Kavuri Svasti Haricharan
author_facet	Nindo B. Punturi Sinem Seker Vaishnavi Devarakonda Aloran Mazumder Rashi Kalra Ching Hui Chen Shunqiang Li Tina Primeau Matthew J. Ellis Shyam M. Kavuri Svasti Haricharan
author_sort	Nindo B. Punturi
title	Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
title_short	Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
title_full	Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
title_fullStr	Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
title_full_unstemmed	Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
title_sort	mismatch repair deficiency predicts response to her2 blockade in her2-negative breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65ef3b7f9a184674b715885b4857dafc
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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

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