The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines

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Autores principales:	Chengzhang Fu, Asfandyar Sikandar, Jannik Donner, Nestor Zaburannyi, Jennifer Herrmann, Michael Reck, Irene Wagner-Döbler, Jesko Koehnke, Rolf Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65f014da62cb460088f5a5ff595c578a
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spelling	oai:doaj.org-article:65f014da62cb460088f5a5ff595c578a2021-12-02T15:39:05ZThe natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD10.1038/s41467-017-01671-52041-1723https://doaj.org/article/65f014da62cb460088f5a5ff595c578a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01671-5https://doaj.org/toc/2041-1723The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell linesChengzhang FuAsfandyar SikandarJannik DonnerNestor ZaburannyiJennifer HerrmannMichael ReckIrene Wagner-DöblerJesko KoehnkeRolf MüllerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chengzhang Fu Asfandyar Sikandar Jannik Donner Nestor Zaburannyi Jennifer Herrmann Michael Reck Irene Wagner-Döbler Jesko Koehnke Rolf Müller The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
description	The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines
format	article
author	Chengzhang Fu Asfandyar Sikandar Jannik Donner Nestor Zaburannyi Jennifer Herrmann Michael Reck Irene Wagner-Döbler Jesko Koehnke Rolf Müller
author_facet	Chengzhang Fu Asfandyar Sikandar Jannik Donner Nestor Zaburannyi Jennifer Herrmann Michael Reck Irene Wagner-Döbler Jesko Koehnke Rolf Müller
author_sort	Chengzhang Fu
title	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
title_short	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
title_full	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
title_fullStr	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
title_full_unstemmed	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
title_sort	natural product carolacton inhibits folate-dependent c1 metabolism by targeting fold/mthfd
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/65f014da62cb460088f5a5ff595c578a
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The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

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