The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/65f014da62cb460088f5a5ff595c578a |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|