trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are effective in eradicating N. gonorrhoeae infection i...

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Autores principales:	Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
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spelling	oai:doaj.org-article:65f0e506e42e4cd09c551a4db2d7e6302021-12-02T13:17:39Ztrans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo10.1038/s41467-021-22012-72041-1723https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e6302021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22012-7https://doaj.org/toc/2041-1723Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are effective in eradicating N. gonorrhoeae infection in mice.Zachary D. AronAtousa MehraniEric D. HofferKristie L. ConnollyPooja SrinivasMatthew C. TorhanJohn N. AlumasaMynthia CabreraDivya HosangadiJay S. BarborSteven C. CardinaleSteven M. KwasnyLucas R. MorinMichelle M. ButlerTimothy J. OppermanTerry L. BowlinAnn JerseScott M. StaggChristine M. DunhamKenneth C. KeilerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zachary D. Aron Atousa Mehrani Eric D. Hoffer Kristie L. Connolly Pooja Srinivas Matthew C. Torhan John N. Alumasa Mynthia Cabrera Divya Hosangadi Jay S. Barbor Steven C. Cardinale Steven M. Kwasny Lucas R. Morin Michelle M. Butler Timothy J. Opperman Terry L. Bowlin Ann Jerse Scott M. Stagg Christine M. Dunham Kenneth C. Keiler trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
description	Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are effective in eradicating N. gonorrhoeae infection in mice.
format	article
author	Zachary D. Aron Atousa Mehrani Eric D. Hoffer Kristie L. Connolly Pooja Srinivas Matthew C. Torhan John N. Alumasa Mynthia Cabrera Divya Hosangadi Jay S. Barbor Steven C. Cardinale Steven M. Kwasny Lucas R. Morin Michelle M. Butler Timothy J. Opperman Terry L. Bowlin Ann Jerse Scott M. Stagg Christine M. Dunham Kenneth C. Keiler
author_facet	Zachary D. Aron Atousa Mehrani Eric D. Hoffer Kristie L. Connolly Pooja Srinivas Matthew C. Torhan John N. Alumasa Mynthia Cabrera Divya Hosangadi Jay S. Barbor Steven C. Cardinale Steven M. Kwasny Lucas R. Morin Michelle M. Butler Timothy J. Opperman Terry L. Bowlin Ann Jerse Scott M. Stagg Christine M. Dunham Kenneth C. Keiler
author_sort	Zachary D. Aron
title	trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
title_short	trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
title_full	trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
title_fullStr	trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
title_full_unstemmed	trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
title_sort	trans-translation inhibitors bind to a novel site on the ribosome and clear neisseria gonorrhoeae in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
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trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

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