Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

Abstract We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained...

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Autores principales:	Eline H. van Roekel, Martijn J. L. Bours, Linda van Delden, Stéphanie O. Breukink, Michèl Aquarius, Eric T. P. Keulen, Audrey Gicquiau, Vivian Viallon, Sabina Rinaldi, Paolo Vineis, Ilja C. W. Arts, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/65f1b265c8214ed484172de96993f415
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spelling	oai:doaj.org-article:65f1b265c8214ed484172de96993f4152021-12-02T16:31:54ZLongitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment10.1038/s41598-021-92279-92045-2322https://doaj.org/article/65f1b265c8214ed484172de96993f4152021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92279-9https://doaj.org/toc/2045-2322Abstract We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value < 0.05) to higher concentrations of arginine, citrulline and histidine, eight lysophosphatidylcholines, nine diacylphosphatidylcholines, 13 acyl-alkylphosphatidylcholines, two sphingomyelins, and acylcarnitine C10:1. No intra-individual associations were found. LPA was not associated with any metabolite. More MVPA was associated with higher concentrations of several lipids and three amino acids, which have been linked to anti-inflammatory processes and improved metabolic health. Mechanistic studies are needed to investigate whether these metabolites may affect prognosis.Eline H. van RoekelMartijn J. L. BoursLinda van DeldenStéphanie O. BreukinkMichèl AquariusEric T. P. KeulenAudrey GicquiauVivian ViallonSabina RinaldiPaolo VineisIlja C. W. ArtsMarc J. GunterMichael F. LeitzmannAugustin ScalbertMatty P. WeijenbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eline H. van Roekel Martijn J. L. Bours Linda van Delden Stéphanie O. Breukink Michèl Aquarius Eric T. P. Keulen Audrey Gicquiau Vivian Viallon Sabina Rinaldi Paolo Vineis Ilja C. W. Arts Marc J. Gunter Michael F. Leitzmann Augustin Scalbert Matty P. Weijenberg Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
description	Abstract We investigated longitudinal associations of moderate-to-vigorous physical activity (MVPA) and light-intensity physical activity (LPA) with plasma concentrations of 138 metabolites after colorectal cancer (CRC) treatment. Self-reported physical activity data and blood samples were obtained at 6 weeks, and 6, 12 and 24 months post-treatment in stage I-III CRC survivors (n = 252). Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQp180 kit). Linear mixed models were used to evaluate confounder-adjusted longitudinal associations. Inter-individual (between-participant differences) and intra-individual associations (within-participant changes over time) were assessed as percentage difference in metabolite concentration per 5 h/week of MVPA or LPA. At 6 weeks post-treatment, participants reported a median of 6.5 h/week of MVPA (interquartile range:2.3,13.5) and 7.5 h/week of LPA (2.0,15.8). Inter-individual associations were observed with more MVPA being related (FDR-adjusted q-value < 0.05) to higher concentrations of arginine, citrulline and histidine, eight lysophosphatidylcholines, nine diacylphosphatidylcholines, 13 acyl-alkylphosphatidylcholines, two sphingomyelins, and acylcarnitine C10:1. No intra-individual associations were found. LPA was not associated with any metabolite. More MVPA was associated with higher concentrations of several lipids and three amino acids, which have been linked to anti-inflammatory processes and improved metabolic health. Mechanistic studies are needed to investigate whether these metabolites may affect prognosis.
format	article
author	Eline H. van Roekel Martijn J. L. Bours Linda van Delden Stéphanie O. Breukink Michèl Aquarius Eric T. P. Keulen Audrey Gicquiau Vivian Viallon Sabina Rinaldi Paolo Vineis Ilja C. W. Arts Marc J. Gunter Michael F. Leitzmann Augustin Scalbert Matty P. Weijenberg
author_facet	Eline H. van Roekel Martijn J. L. Bours Linda van Delden Stéphanie O. Breukink Michèl Aquarius Eric T. P. Keulen Audrey Gicquiau Vivian Viallon Sabina Rinaldi Paolo Vineis Ilja C. W. Arts Marc J. Gunter Michael F. Leitzmann Augustin Scalbert Matty P. Weijenberg
author_sort	Eline H. van Roekel
title	Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
title_short	Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
title_full	Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
title_fullStr	Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
title_full_unstemmed	Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
title_sort	longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65f1b265c8214ed484172de96993f415
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Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment

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