Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study

Trace elements play an important role in metabolism. We compared the daily intake and serum concentrations of copper (Cu), selenium (Se), and zinc (Zn) across a spectrum of glucose tolerance status in a representative U.S. population. Daily intake and serum concentrations of Cu, Zn and Se in 5087 ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vishwanath Pattan, Maria Mercedes Chang Villacreses, Rudruidee Karnchanasorn, Ken C. Chiu, Raynald Samoa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	trace element copper selenium zinc diabetes mellitus glucose metabolism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/65f330c9977d42798fbf6107b12e06fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:65f330c9977d42798fbf6107b12e06fb
record_format	dspace
spelling	oai:doaj.org-article:65f330c9977d42798fbf6107b12e06fb2021-11-25T18:36:22ZDaily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study10.3390/nu131140442072-6643https://doaj.org/article/65f330c9977d42798fbf6107b12e06fb2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4044https://doaj.org/toc/2072-6643Trace elements play an important role in metabolism. We compared the daily intake and serum concentrations of copper (Cu), selenium (Se), and zinc (Zn) across a spectrum of glucose tolerance status in a representative U.S. population. Daily intake and serum concentrations of Cu, Zn and Se in 5087 adults from the 2011–2016 National Health and Nutrition Examination Survey (NHANES) were examined and compared to normal (NGT) and abnormal (AGT) glucose tolerance and the presence of diabetes mellitus (DM). Other than Zn deficiency (21.15%), the prevalence of Zn, Se, and Cu excess and Se and Cu deficiency were low (<4.00%). As compared to the NGT group, Cu and Se supplementation was higher in the AGT and DM groups (<i>p</i> < 0.0001 for all). Serum Se and Zn, but not Cu, concentrations were highly correlated with daily intake (<i>p</i> < 0.0001 for both). As compared to the NGT group, serum Cu concentration was highest in the AGT group (<i>p</i> = 0.03), serum Se concentration was highest in the DM group (<i>p</i> < 0.0001), and serum Zn concentration was highest in the AGT group (<i>p</i> < 0.0001). Serum Se and Zn concentration was correlated with daily Se and Zn intake. Even within the reference range for serum Cu, Se, and Zn concentrations, a higher serum concentration of Cu, Se, and Zn was associated with abnormal glucose metabolism. Although the casual relationship remains to be elucidated, these data suggest caution in Cu, Se and Zn supplementation in non-deficient individuals.Vishwanath PattanMaria Mercedes Chang VillacresesRudruidee KarnchanasornKen C. ChiuRaynald SamoaMDPI AGarticletrace elementcopperseleniumzincdiabetes mellitusglucose metabolismNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4044, p 4044 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trace element copper selenium zinc diabetes mellitus glucose metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	trace element copper selenium zinc diabetes mellitus glucose metabolism Nutrition. Foods and food supply TX341-641 Vishwanath Pattan Maria Mercedes Chang Villacreses Rudruidee Karnchanasorn Ken C. Chiu Raynald Samoa Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
description	Trace elements play an important role in metabolism. We compared the daily intake and serum concentrations of copper (Cu), selenium (Se), and zinc (Zn) across a spectrum of glucose tolerance status in a representative U.S. population. Daily intake and serum concentrations of Cu, Zn and Se in 5087 adults from the 2011–2016 National Health and Nutrition Examination Survey (NHANES) were examined and compared to normal (NGT) and abnormal (AGT) glucose tolerance and the presence of diabetes mellitus (DM). Other than Zn deficiency (21.15%), the prevalence of Zn, Se, and Cu excess and Se and Cu deficiency were low (<4.00%). As compared to the NGT group, Cu and Se supplementation was higher in the AGT and DM groups (<i>p</i> < 0.0001 for all). Serum Se and Zn, but not Cu, concentrations were highly correlated with daily intake (<i>p</i> < 0.0001 for both). As compared to the NGT group, serum Cu concentration was highest in the AGT group (<i>p</i> = 0.03), serum Se concentration was highest in the DM group (<i>p</i> < 0.0001), and serum Zn concentration was highest in the AGT group (<i>p</i> < 0.0001). Serum Se and Zn concentration was correlated with daily Se and Zn intake. Even within the reference range for serum Cu, Se, and Zn concentrations, a higher serum concentration of Cu, Se, and Zn was associated with abnormal glucose metabolism. Although the casual relationship remains to be elucidated, these data suggest caution in Cu, Se and Zn supplementation in non-deficient individuals.
format	article
author	Vishwanath Pattan Maria Mercedes Chang Villacreses Rudruidee Karnchanasorn Ken C. Chiu Raynald Samoa
author_facet	Vishwanath Pattan Maria Mercedes Chang Villacreses Rudruidee Karnchanasorn Ken C. Chiu Raynald Samoa
author_sort	Vishwanath Pattan
title	Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
title_short	Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
title_full	Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
title_fullStr	Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
title_full_unstemmed	Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study
title_sort	daily intake and serum levels of copper, selenium and zinc according to glucose metabolism: cross-sectional and comparative study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/65f330c9977d42798fbf6107b12e06fb
work_keys_str_mv	AT vishwanathpattan dailyintakeandserumlevelsofcopperseleniumandzincaccordingtoglucosemetabolismcrosssectionalandcomparativestudy AT mariamercedeschangvillacreses dailyintakeandserumlevelsofcopperseleniumandzincaccordingtoglucosemetabolismcrosssectionalandcomparativestudy AT rudruideekarnchanasorn dailyintakeandserumlevelsofcopperseleniumandzincaccordingtoglucosemetabolismcrosssectionalandcomparativestudy AT kencchiu dailyintakeandserumlevelsofcopperseleniumandzincaccordingtoglucosemetabolismcrosssectionalandcomparativestudy AT raynaldsamoa dailyintakeandserumlevelsofcopperseleniumandzincaccordingtoglucosemetabolismcrosssectionalandcomparativestudy
_version_	1718410895232598016

Daily Intake and Serum Levels of Copper, Selenium and Zinc According to Glucose Metabolism: Cross-Sectional and Comparative Study

Ejemplares similares