Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration

Suppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression.

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Autores principales:	Xin Chen, Sarah M. Lloyd, Junghun Kweon, Giovanni M. Gamalong, Xiaomin Bao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65f40b92b773475c8ead94676c9fa129
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spelling	oai:doaj.org-article:65f40b92b773475c8ead94676c9fa1292021-12-02T10:49:32ZEpidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration10.1038/s41467-020-20674-32041-1723https://doaj.org/article/65f40b92b773475c8ead94676c9fa1292021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20674-3https://doaj.org/toc/2041-1723Suppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression.Xin ChenSarah M. LloydJunghun KweonGiovanni M. GamalongXiaomin BaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
description	Suppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression.
format	article
author	Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao
author_facet	Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao
author_sort	Xin Chen
title	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
title_short	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
title_full	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
title_fullStr	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
title_full_unstemmed	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
title_sort	epidermal progenitors suppress grhl3-mediated differentiation through intronic polyadenylation promoted by cpsf-hnrnpa3 collaboration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/65f40b92b773475c8ead94676c9fa129
work_keys_str_mv	AT xinchen epidermalprogenitorssuppressgrhl3mediateddifferentiationthroughintronicpolyadenylationpromotedbycpsfhnrnpa3collaboration AT sarahmlloyd epidermalprogenitorssuppressgrhl3mediateddifferentiationthroughintronicpolyadenylationpromotedbycpsfhnrnpa3collaboration AT junghunkweon epidermalprogenitorssuppressgrhl3mediateddifferentiationthroughintronicpolyadenylationpromotedbycpsfhnrnpa3collaboration AT giovannimgamalong epidermalprogenitorssuppressgrhl3mediateddifferentiationthroughintronicpolyadenylationpromotedbycpsfhnrnpa3collaboration AT xiaominbao epidermalprogenitorssuppressgrhl3mediateddifferentiationthroughintronicpolyadenylationpromotedbycpsfhnrnpa3collaboration
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Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration

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