Discovering human diabetes-risk gene function with genetics and physiological assays

The function of genes linked to type 2 diabetes is poorly characterized. Here the authors combine Drosophila genetics and physiology with human islet biology to identify new regulators of insulin secretion including BCL11A.

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Autores principales:	Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, Olof Asplund, Gregory C. Ippolito, Rita Bottino, Leif Groop, Haley Tucker, Seung K. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/65f824bf8be94cd8aa40a81965f1d6da
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spelling	oai:doaj.org-article:65f824bf8be94cd8aa40a81965f1d6da2021-12-02T17:31:59ZDiscovering human diabetes-risk gene function with genetics and physiological assays10.1038/s41467-018-06249-32041-1723https://doaj.org/article/65f824bf8be94cd8aa40a81965f1d6da2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06249-3https://doaj.org/toc/2041-1723The function of genes linked to type 2 diabetes is poorly characterized. Here the authors combine Drosophila genetics and physiology with human islet biology to identify new regulators of insulin secretion including BCL11A.Heshan PeirisSangbin ParkShreya LouisXueying GuJonathan Y. LamOlof AsplundGregory C. IppolitoRita BottinoLeif GroopHaley TuckerSeung K. KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heshan Peiris Sangbin Park Shreya Louis Xueying Gu Jonathan Y. Lam Olof Asplund Gregory C. Ippolito Rita Bottino Leif Groop Haley Tucker Seung K. Kim Discovering human diabetes-risk gene function with genetics and physiological assays
description	The function of genes linked to type 2 diabetes is poorly characterized. Here the authors combine Drosophila genetics and physiology with human islet biology to identify new regulators of insulin secretion including BCL11A.
format	article
author	Heshan Peiris Sangbin Park Shreya Louis Xueying Gu Jonathan Y. Lam Olof Asplund Gregory C. Ippolito Rita Bottino Leif Groop Haley Tucker Seung K. Kim
author_facet	Heshan Peiris Sangbin Park Shreya Louis Xueying Gu Jonathan Y. Lam Olof Asplund Gregory C. Ippolito Rita Bottino Leif Groop Haley Tucker Seung K. Kim
author_sort	Heshan Peiris
title	Discovering human diabetes-risk gene function with genetics and physiological assays
title_short	Discovering human diabetes-risk gene function with genetics and physiological assays
title_full	Discovering human diabetes-risk gene function with genetics and physiological assays
title_fullStr	Discovering human diabetes-risk gene function with genetics and physiological assays
title_full_unstemmed	Discovering human diabetes-risk gene function with genetics and physiological assays
title_sort	discovering human diabetes-risk gene function with genetics and physiological assays
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/65f824bf8be94cd8aa40a81965f1d6da
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Discovering human diabetes-risk gene function with genetics and physiological assays

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